Cephalexin Granules

1 Pharmacology Cephalexin is a first-generation cephalosporin with an antibacterial spectrum similar to that of cephalothin, but its antibacterial activity is poorer than that of the latter. Except for Enterococcus and methicillin-resistant Staphylococci, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and Staphylococcus aureus that produces or does not produce penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; this product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are moderately sensitive to this product. 2 Toxicity The oral median lethal dose of cephalexin in mice is 2600 mg/kg.

The main ingredient of this product is cephalexin, and its chemical name is (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate.

This product is a granule with flavoring agent added.

It is suitable for acute tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia and other respiratory tract infections, urinary tract infections and skin and soft tissue infections caused by sensitive bacteria. This product is an oral preparation and should not be used for severe infections.

Adult dosage: Oral, generally 250-500 mg once, 4 times a day, the highest dose is 4g per day. Patients with impaired renal function should reduce the dosage according to the degree of renal function impairment. Patients with simple cystitis, skin and soft tissue infections and streptococcal pharyngitis should take 500 mg every 12 hours. Children's dosage: Oral, 25-50 mg/kg per day, 4 times a day. Patients with skin and soft tissue infections and streptococcal pharyngitis should take 12.5-50 mg/kg once, twice a day.

1 Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2 Allergic reactions such as rash and drug fever. Occasionally, anaphylactic shock may occur. 3 Nervous system reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4 Renal damage may occasionally occur during the use of this product. 5 Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported.

It is contraindicated in patients who are allergic to cephalosporins or have a history of anaphylactic shock or immediate reaction to penicillin.

1. When combined with cholestyramine (cholestyramine), the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the renal excretion of this product, and there are also reports that probenecid can increase the excretion of this product in bile.

Keep away from light, seal tightly and store in a cool dark place.

0.125g

Kunming Jida Pharmaceutical Co., Ltd.

• Founded in:

  1993-08-14

• Address:

  No. 389, Kexin Road, High-tech Development Zone, Kunming, Yunnan Province

• Tax NO.:

  91530000622600182R

• Registered Funds:

  370 million yuan

• Website:

  Log in to view

• Email:

  Log in to view