Cefixime Capsules
Function and Efficacy
It has a wide range of antibacterial effects on both Gram-positive and Gram-negative bacteria, especially on Streptococcus and Pneumococcus among Gram-positive bacteria, and Gonorrhea, Borrelia, Escherichia coli, Klebsiella, Serratia, Proteus, and Haemophilus influenzae among Gram-negative bacteria. It has stronger antibacterial ability than other oral cephalosporins, and its mode of action is bactericidal. Since this product is extremely stable to β-lactamase produced by various bacteria, it also has excellent antibacterial power against bacteria that produce β-lactamase. The mechanism of action of this product is mainly to prevent the synthesis of bacterial cell walls.
Ingredients
Cefixime. Chemical name: 7{[2-amino-4-thiazolyl[hydroxymethoxy|imine|-acetyl]amino-3-vinyl-8-oxo-5-thia-1-azabicyclo|4,2,O]}-2-octane-2-carboxylic acid. Chemical structure: Molecular formula: C16H15N5O7S2 Molecular weight: 453.44
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| CefiximeIngredients |
It has a wide range of antibacterial effects on both Gram-positive and Gram-negative bacteria, especially on Streptococcus and Pneumococcus among Gram-positive bacteria, and Gonorrhea, Borrelia, Escherichia coli, Klebsiella, Serratia, Proteus, and Haemophilus influenzae among Gram-negative bacteria. Since this product is extremely stable to β-lactamase produced by various bacteria, it also has excellent antibacterial properties against bacteria that produce β-lactamase. The main mechanism of action is to prevent the synthesis of bacterial cell walls. More |
79350-37-1 | 50 |
Appearance
This product is a hard capsule. After removing the capsule, the contents are white or light yellow powder.
Indication
Broad-spectrum antibiotic. Effective against infections caused by Streptococcus, Pneumococcus, Gonorrhea, Borrelia, Escherichia coli, Klebsiella, Serratia, Proteus, and Haemophilus influenzae. Mainly used to treat bronchitis, bronchiectasis and infection, secondary infection of chronic respiratory diseases, pneumonia, pyelonephritis, cystitis, gonococcal urethritis, cholecystitis, cholangitis
Usage and Dosage
Oral administration: 50-100 mg twice a day for adults and children weighing more than 30 kg. In severe cases, the dose can be increased to 0.2 g twice a day.
Adverse Reactions
The main symptoms are diarrhea, abnormal stool, headache, nausea, abdominal pain, rash, etc. In a very small number of patients, GPT and GOT are elevated.
Precautions
Patients with a history of allergy to this product or to cephalosporin antibiotics are contraindicated.
Special Population Medication
Precautions for children: The safety and efficacy of cefixime for children under 6 months of age have not been determined. Precautions for pregnancy and lactation: Reproductive studies in mice and rats at doses up to 400 times the human dose showed no evidence of damage to fetal mice. The safety of the drug during pregnancy has not been determined, so when using the drug for pregnant women or women who may become pregnant, the pros and cons must be weighed, and the drug can only be used when the benefits outweigh the cons. The effect of cefixime on delivery has not been studied, and it can only be used when it is clearly needed. It is unclear whether cefixime is excreted in human milk. When using this product, consider suspending breastfeeding. Precautions for the elderly: 1. The peak blood concentration and AUC of this product in the elderly can be 26% and 20% higher than those in young people, respectively, and the elderly can use this product. 2. Patients with renal insufficiency should adjust the dosage, and patients with a creatinine clearance of ge; 60ml/min can use it according to the normal dose and course of treatment. Patients with a creatinine clearance of 21~60ml/min or hemodialysis can be given at 75% of the standard dose (standard dosing interval). Patients with creatinine clearance of 20 ml/min or long-term bedridden peritoneal dialysis can be given half the standard dose (standard dosing interval).
Drug Interactions
(1) This product is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. Occasionally, this product may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. (2) The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. (4) Clavulanic acid can increase the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of B-lactamase.
Storage
Sealed, store in a cool, dry place.
Packaging Specification
50mg
Validity Period
24 months
Manufacturer
Shanghai Hengshan Pharmaceutical Co., Ltd.
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Founded in:
1981-07-20 -
Address:
No. 176, Zidong Road, Minhang District, Shanghai -
Tax NO.:
91310112132628617W -
Registered Funds:
47.46 million yuan -
Website:
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Email: