Cefotezol Sodium for Injection

Ceftezole sodium is a semi-synthetic cephalosporin derivative, and its mechanism of action is to exert antibacterial activity by inhibiting the synthesis of bacterial cell walls. Ceftezole sodium has antibacterial activity against the following bacteria: 1. Aerobic Gram-positive bacteria: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. 2. Aerobic Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus.

This product is a sterile powder of ceftezole sodium. Its chemical name is: sodium (6R, 7R)-3-[(1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.

Sepsis, pneumonia, bronchitis, bronchiectasis (in case of infection), secondary infection of chronic respiratory diseases, lung abscess, peritonitis, pyelonephritis, cystitis, urethritis.

Adults take 0.5g~2g (2~8 vials) at a time, twice a day, intravenously or intramuscularly. For severe infections, the dose can be appropriately increased as prescribed by the doctor. Preparation of injection: 1. Intravenous injection: Dissolve in water for injection, normal saline or 5% glucose injection, and inject slowly. 2. Intravenous drip: Dissolve in normal saline or 5% glucose injection. 3. Intramuscular injection: Dissolve in 0.5% lidocaine hydrochloride injection. If the injection becomes turbid due to temperature reasons when it is dissolved, it can be heated to clarify it before use. It is best to use it immediately after dissolution. If it needs to be stored, it should be stored in a cool place (below 15°C) to prevent precipitation, but it must be used within 72 hours.

1. Shock: Shock rarely occurs, and close observation is required. If any symptoms related to the use of this product occur, such as discomfort, abnormal sensation in the mouth, asthma, dizziness, sudden abnormal bowel movements, tinnitus, sweating, etc., the drug should be stopped immediately and necessary treatment should be given. 2. A few have allergic reactions, such as rash, urticaria, skin redness, itching, fever, etc., which disappear when the drug is stopped. 3. Severe renal function abnormalities are rare, and blood creatinine is occasionally increased. If abnormalities are found, the drug should be stopped immediately and necessary treatment should be given. 4. Granulocytopenia, leukopenia, eosinophilia, thrombocytopenia, etc. are rare. When the above abnormalities are found, the drug should be stopped. 5. GOT, GPT, and alkaline phosphatase increase are rare. When the above abnormalities occur, the drug should be stopped immediately. 6. Gastrointestinal reactions, such as nausea, vomiting, diarrhea, etc. are rare, and pseudomembranous colitis is rare. When abdominal pain and diarrhea occur, the drug should be stopped immediately. 7. Dysbacteriosis: Candida infection rarely occurs. 8. Vitamin deficiency: Vitamin K deficiency and B vitamin deficiency are rare. 9. Interstitial pneumonia, toxic fever, cough, dyspnea, abnormal chest X-ray, eosinophilia are rare. When the above symptoms occur, the drug should be discontinued and appropriate treatment should be given. 10. Others: Headache, general malaise, fever, superficial glossitis are rare.

1. Patients who are allergic to this product or other cephalosporin antibiotics are contraindicated. 2. Patients who have a history of allergy to lidocaine or acylanilide local anesthetics are contraindicated for intramuscular injection of this product. [Use in pregnant and lactating women] The safety of using the drug during pregnancy has not yet been determined. For pregnant women or women who may become pregnant, the pros and cons must be weighed, and the drug can only be used when the pros outweigh the cons. Therefore, pregnant and lactating women should use it with caution. [Use in children] Children should take 10 to 40 mg per kilogram of body weight once, twice a day, intravenously or intramuscularly (for the preparation of the injection, see: Dosage and Administration).

Not yet clear.

Sealed and stored at room temperature. Valid for 2 years.

0.75g based on ceftizole

CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

• Founded in:

  1997-12-12

• Address:

  No. 88, Yangzi Road, Shijiazhuang Economic and Technological Development Zone, Hebei Province

• Tax NO.:

  91130100601908022F

• Registered Funds:

  678.5559 million yuan

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