Econazole nitrate cream
Function and Efficacy
This product is an azole antifungal drug and a dechlorinated derivative of miconazole. This product has antibacterial effects on Candida, Chromatiaceae, Coccidioides, Histoplasma, Sporothrix, etc., and also has antibacterial activity against Trichophyton, etc. This product has poor effects on Aspergillus, Sporothrix Schenckii, some dark-colored spores, Mucor, etc. This product inhibits the biosynthesis of ergosterol, the main steroid of fungal cell membrane, by interfering with the activity of cytochrome P-450, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. This product can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, cause the accumulation of hydrogen peroxide in cells, and lead to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae.
Ingredients
The main ingredients of this product are: Econazole nitrate. Chemical name: 1-[2,4-dichloro-β(4-chlorobenzyloxy)phenethyl]imidazole nitrate. Molecular formula: C18H15Cl3N2O·HNO3 Molecular weight: 444.70
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Econazole nitrateIngredients |
This product is an azole antifungal drug, which has antibacterial effects on Candida, Chromatiaceae, Coccidioides, Histoplasma, Sporothrix, etc., and also has antibacterial activity against Trichophyton, etc. It interferes with the activity of cytochrome P-450, inhibits the biosynthesis of ergosterol, the main steroid of fungal cell membrane, damages the fungal cell membrane and changes its permeability, leading to leakage of important intracellular substances. It can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidase and peroxidase, cause the accumulation of hydrogen peroxide in cells, and lead to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae. More |
68797-31-9 | 18 |
Appearance
This product is a milky white cream.
Indication
Used for the treatment of skin candidiasis; can also be used to treat tinea corporis, tinea cruris, tinea pedis, and tinea versicolor.
Usage and Dosage
Topical application: For skin candidiasis and various tinea, apply once in the morning and evening each day, for 2 to 4 weeks; for tinea versicolor, apply once a day.
Adverse Reactions
Some patients experience local irritation and occasionally allergic reactions, manifested as burning sensation, itching, tingling, congestion, etc.
Precautions
It is contraindicated for those who are allergic to this product.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use under the guidance of a physician. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Seal and store in a cool place (not exceeding 20℃). Valid for 24 months.
Packaging Specification
10g:0.1g
Validity Period
24 months
Manufacturer
Changzhou Siyao Pharmaceuticals Co., Ltd.
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Founded in:
1996-03-25 -
Address:
Meilongba, southern suburb of Changzhou, Jiangsu Province -
Tax NO.:
91320400608126461P -
Registered Funds:
$7.08 million -
Website:
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Email: