Halcinonide Cream
Function and Efficacy
1 Anti-inflammatory effect This product is a topical drug, a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-itching and vasoconstriction effects. This product replaces the 21-hydroxyl group with a chlorine atom on the skeleton of triamcinolone. Its anti-inflammatory potency is 360 times as determined by the vasoconstriction test. There is evidence that the intensity of the vasoconstriction test is consistent with the efficacy. Its anti-inflammatory and antipruritic mechanism is to increase the reactivity of b receptors to catecholamine, increase the production of cAMP by activating adenylate cyclase, and reduce the destruction of cAMP by inhibiting phosphoethylesterase, resulting in an increase in the annual concentration of cAMP in cells and inhibiting the release of histamine. The effect of this product in inhibiting the proliferation of granulomas in rats and mice is similar to that of dexamethasone. Using the formaldehyde-induced heel swelling method for mice and rats, this product and dexamethasone both have significant inhibitory effects, while hydrocortisone with a 5-fold higher dose has no inhibitory effect. This product has a significant weight loss effect on the thymus and spleen. 2 Selective pharmacological effects on various types of cells: reduce the number of T lymphocytes, monocytes, and eosinophils, inhibit lymphocyte proliferation and cytokine production, inhibit macrophage differentiation and phagocytic activity, inhibit neutrophil adhesion, reduce vascular endothelial cell permeability, inhibit fibroblast proliferation and collagen synthesis, and inhibit sebaceous gland cell activity. 3 Anti-proliferative effect This product has an anti-mitotic effect. It reduces the transcription of PNA, thereby reducing DNA synthesis, and also affects DNA repair, resulting in thinning of the epidermis, especially the greatest impact on collagen synthesis. 4 Immunosuppressive effect This product binds to the corticosteroid receptors in the cytoplasm, causing a series of reactions and activating the expression of lytic genes in the cells; it induces nuclear DNA lysis in lymphocytes and directly kills lymphocytes.
Ingredients
Halcinonide (clofosinolone, halcinonide). Chemical name: 16,17-[(1-methylethylidene)bis(oxy)-11-hydroxy-21-chloro-9-fluoropregnane-4-ene-3,20-dione.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| HalcinonideIngredients |
This product is a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive effects. Its anti-inflammatory and antipruritic mechanism is to increase the responsiveness of b receptors to catecholamine, increase the production of cAMP by activating adenylate cyclase, and inhibit phosphoethylesterase to reduce the destruction of cAMP, resulting in an increase in the concentration of cAMP in cells and inhibiting the release of histamine. This product has a similar effect as dexamethasone in inhibiting the proliferation of granulomas in rats and mice; it has a significant weight-reducing effect on the thymus and spleen; it reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity; it has an anti-mitotic effect, reduces PNA transcription, thereby reducing DNA synthesis, and also affects DNA repair, causing the epidermis to become thinner, especially having the greatest effect on collagen synthesis; it activates lytic gene expression and induces nuclear DNA lysis in lymphocytes to directly kill lymphocytes by binding to the cytoplasmic corticosteroid receptors. More |
3093-35-4 | 9 |
Appearance
This product is a milky white cream.
Indication
Contact eczema, atopic dermatitis, neurodermatitis, small-scale psoriasis, lichen sclerosus atrophicus, lichen planus, discoid lupus erythematosus, seborrheic dermatitis (non-facial) hypertrophic scars.
Usage and Dosage
Apply to the affected area once in the morning and evening.
Adverse Reactions
A small number of patients experience burning sensation, stinging, and temporary itching at the site of application. Long-term use may cause dilation of skin capillaries (especially on the face), skin atrophy, and stretch marks (prone to adolescents). Skin atrophy may be followed by purpura, ecchymosis, skin fragility, hirsutism, folliculitis, miliary papules, skin depigmentation, and delayed ulcer healing. The packing method is prone to secondary fungal infection in skin folds. When absorbed through the skin for a long time, systemic adverse reactions may occur.
Precautions
Allergic reactions to the drug. Primary skin lesions caused by bacteria, fungi, viruses and parasites. Ulcerative lesions. Acne, rosacea. Use on the eyelids (risk of causing glaucoma). Exudative skin diseases.
Special Population Medication
Precautions for children: It should be applied to a small area and for a short period of time. Once the symptoms subside, stop the drug immediately. Children under one year old should try not to use this drug. Avoid long-term and large-scale sealed drug administration. Precautions for pregnancy and lactation: There is no research on the teratogenic effect of topical medication. It should be used with caution during pregnancy. When applied topically, a large amount of it can be excreted from breast milk. It should be used with caution during lactation. Precautions for the elderly: Avoid long-term and large-scale sealed drug administration.
Drug Interactions
Not yet clear
Storage
Store tightly closed at room temperature.
Packaging Specification
10g:10mg
Validity Period
36 months
Manufacturer
Tianjin Pacific Pharmaceutical Co., Ltd.
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Founded in:
1994-08-08 -
Address:
Economic Development Zone, Xiqing District, Tianjin -
Tax NO.:
91120111600584134N -
Registered Funds:
133.19 million yuan -
Website:
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Email: