Metacycline Hydrochloride Capsules

This product belongs to the tetracycline antibiotics. Some strains resistant to tetracycline or oxytetracycline may still be sensitive to this product. Many Rickettsia, Mycoplasma, Chlamydia, some atypical mycobacteria, and spirochetes are sensitive to this product, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to methacycline. Due to the widespread use of tetracyclines over the years, common clinical pathogens are seriously resistant to methacycline, including Gram-positive bacteria such as Staphylococcus and most Enterobacteriaceae. There is cross-resistance between this product and different varieties of tetracyclines.

The main ingredient of this product is metacycline hydrochloride, and its chemical name is [4S-(4α,4aα,5α,5aα,12aα)]-6-methylene-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride.

This product is in the form of capsules.

1 This product can be used as a first-line or optional drug for the following diseases: (1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever. (2) Mycoplasma infections. (3) Chlamydia infections, including psittacosis, lymphogranuloma venereum, non-gonococcal urethritis, salpingitis, cervicitis and trachoma. (4) Relapsing fever. (5) Brucellosis. (6) Cholera. (7) Tularemia. (8) Plague. (9) Chancroid. It should be used in combination with aminoglycosides to treat brucellosis and plague. 2

Adults: 300 mg orally every 12 hours; children over 8 years old: 5 mg/kg body weight every 12 hours.

1 Digestive system: Gastrointestinal symptoms such as nausea, vomiting, upper abdominal discomfort, bloating, diarrhea, and occasionally pancreatitis. There are occasional reports of esophagitis and esophageal ulcers, which mostly occur in patients who go to bed immediately after taking the medicine. 2 Hepatotoxicity: Usually fatty liver degeneration, which is prone to occur in pregnant women and patients with pre-existing renal damage, and can also occur in patients without the above conditions. Pancreatitis caused by this product can also occur simultaneously with hepatotoxicity, and the patient does not have primary liver disease. 3 Allergic reactions: Mostly maculopapular rash and erythema, in addition to urticaria, angioedema, allergic purpura, pericarditis and worsening of skin lesions of systemic lupus erythematosus, exfoliative dermatitis is not common. Occasionally anaphylactic shock and asthma occur. Certain

Patients with a history of allergy to tetracyclines are contraindicated.

1 When used with antacids such as sodium bicarbonate, the absorption of this product may be reduced and its activity may be reduced due to the increase in gastric pH. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2 Drugs containing metal ions such as calcium, magnesium, and iron may form insoluble complexes with this product, reducing the absorption of this product after oral administration. 3 When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity may be enhanced. 4 When used in combination with strong diuretics such as furosemide, renal damage may be aggravated. 5 When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage may be aggravated. 6 The lipid-lowering drugs colestyramine or colestipol may affect the absorption of this product.

Sealed, store in a cool, dry place.

0.1g (calculated as C22H22N2O8)

Henan Runhong Pharmaceutical Co., Ltd.

• Founded in:

  2002-06-26

• Address:

  No. 227, Qing'an Road, Xinzheng City

• Tax NO.:

  914101007407005718

• Registered Funds:

  340.484 million yuan

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