Ceftriaxone Sodium

This product is a third-generation cephalosporin antibiotic. It has strong activity against Enterobacteriaceae. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter fluorescens, indole-positive Proteus, Providencia and Serratia is between 0.12 and 0.25 mg/L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa are poorly sensitive to this product. It has a strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has a good effect on hemolytic streptococci and pneumococci. The MIC for Staphylococcus aureus is 2 to 4 mg/L. Methicillin-resistant Staphylococci and enterococci are resistant to this product. Most Bacteroides fragilis are resistant to this product.

The main ingredient of this product is cefuroxime sodium, and its chemical name is [6R-[6a,7b(Z)]]-7[[2,3-dihydro-2-imino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt.

This product is white or off-white crystalline powder; odorless.

Prevention of various infections caused by sensitive bacteria such as respiratory tract infections, urinary tract infections (including pyelonephritis and gonorrhea), sepsis, meningitis, burn infections, postoperative infections, bone and joint, soft tissue, skin and wound infections, abdominal infections (peritonitis, bile duct and gastrointestinal tract infections) and perioperative infections.

Oral. 1. Common dosage for adults: 0.25-0.5g once, once every 6 hours. For more serious infections, the dosage can be increased to 1g once, but the total daily dosage should not exceed 4g. 2. Common dosage for children: 6.25-12.5mg/kg once according to body weight, once every 6 hours. 3. During treatment, regardless of the patient's age and weight, the maximum dose of cefradine that can be taken is 1g/time, once every 6 hours. As with other antibacterial treatments, cefradine treatment should be continued at least until the patient's infection symptoms disappear or at least 48-72 hours after evidence of bacterial clearance is obtained. When treating infections caused by group A B-hemolytic streptococci, it is recommended to treat for at least 10 days to prevent the occurrence of rheumatic fever or glomerulonephritis.

Adverse reactions are related to the dosage and course of treatment. Local reactions include phlebitis (1.86%), in addition to allergic reactions such as rash, itching, fever, bronchospasm and serum sickness (2.77%), headache or dizziness (0.27%), diarrhea, nausea, vomiting, abdominal pain, colitis, jaundice, flatulence, taste disorders and indigestion and other digestive tract reactions (3.45%). About 19% of laboratory tests were abnormal, of which 14% were abnormal in hematological tests, including eosinophilia, thrombocytosis or thrombocytopenia and leukopenia. Abnormal liver and kidney function was 5% and 1.4% respectively.

It is contraindicated in patients who are allergic to cephalosporin antibiotics.

Precautions for children: Newborns with jaundice or a tendency to jaundice should use with caution or avoid using. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women.

1. When erythromycin, tetracycline, amphotericin B, vasoactive drugs (meta-hydroxylamine, norepinephrine, etc.), phenytoin sodium, chlorpromazine, isopropyl alcohol, vitamin B group, vitamin C, etc. are added to the intravenous infusion of cephalosporins, turbidity will occur. Since this product has many contraindications, it should be administered alone. 2. When drinking alcohol or taking alcohol-containing drugs during the use of this product, some patients may have a disulfiram-like reaction. Therefore, drinking alcohol and taking alcohol-containing drugs should be avoided during the use of this product and in the following days.

Keep away from light, tightly sealed, in a dry and cool place

Harbin Pharmaceutical Group Co., Ltd. GENERAL Pharm. FACTORY

• Founded in:

  1994-05-19

• Address:

  No. 388, Hahei Highway, Hulan District (production base No. 109, Xuefu Road, Nangang District, No. 1, Junmin Street, Xiangfang District)

• Tax NO.:

  912301008280277137

• Registered Funds:

  -

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