Prednisolone Acetate Injection

This product is a drug of the adrenal cortex hormone class. It has multiple pharmacological effects such as anti-inflammatory, anti-allergic and immunosuppressive. (1) Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. (2) Immunosuppressive effect: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, and reduce the expansion of primary immune responses. (3) Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a protective role; they are also commonly used in clinical practice to treat severe shock, especially toxic shock.

Prednisolone acetate

This product is a suspension of fine particles. The fine particles sink after standing and become a uniform milky white suspension after shaking.

It is mainly used for allergic and autoimmune inflammatory diseases. It is now used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, nephrotic syndrome, thrombocytopenic purpura, granulocytopenia, various adrenal insufficiency, severe dermatitis, acute leukemia, etc. It is also used for the comprehensive treatment of certain infections.

Intramuscular or intra-articular injection: 10-40 mg per day (2/25-8/25 vials), the dose can be increased if necessary.

There are no obvious adverse reactions when glucocorticoids are used in physiological dose replacement therapy. Adverse reactions mostly occur when the pharmacological dose of the drug is used, and are closely related to the course of treatment, dosage, type of medication, usage and route of administration. For example, the systemic adverse reactions caused by intra-articular injection of this product are relatively few and mild. Common adverse reactions are as follows: 1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome facial and body shape, weight gain, lower limb edema, purple lines, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, pathological fractures of long bones), muscle weakness, muscular atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, and growth of children is affected.

It is contraindicated for those who are allergic to this product and steroid hormone drugs. It is generally not suitable for patients with the following diseases. In special circumstances, the pros and cons should be weighed and attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fracture, trauma repair period, corneal ulcer, hyperadrenocorticism, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibiotics such as chickenpox, measles, fungal infections, severe osteoporosis, etc.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time. Precautions for pregnancy and lactation: 1. Medication during pregnancy: Glucocorticoids can pass through the placenta. Animal experimental studies have confirmed that administration during pregnancy can increase the incidence of cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. The use of pharmacological doses of glucocorticoids in humans can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. 2. Medication during lactation: Since glucocorticoids can be excreted in breast milk, they can cause adverse effects on infants, such as growth inhibition and adrenal cortex function inhibition. Pregnant and lactating women should avoid using them as much as possible after weighing the pros and cons. Precautions for the elderly: Elderly patients are prone to hypertension and diabetes when using glucocorticoids. Elderly patients, especially postmenopausal women, are prone to aggravating osteoporosis when using glucocorticoids.

⑴ Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. ⑵ It can enhance the hepatotoxicity of acetaminophen. ⑶ When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors is prone to hypocalcemia and osteoporosis. ⑷ When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. ⑸ When used in combination with anticholinergics (such as atropine) for a long time, it can cause increased intraocular pressure. ⑹ Tricyclic antidepressants can aggravate the mental symptoms caused by it. ⑺ When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase the blood sugar of diabetic patients. ⑻ Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. ⑼ When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. ⑽ When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. ⑾ When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. ⑿ When used in combination with ephedrine, it can enhance its metabolic clearance. ⒀ When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. ⒁ It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. ⒂ It can promote the metabolism of mexiletine in the body and reduce the blood concentration. ⒃ When used in combination with salicylates, it can reduce the concentration of plasma salicylate. ⒄ When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

Keep tightly closed in a cool, dark and dry place.

1ml:25mg

18 months

Zhejiang Xianju Pharmaceutical Co., Ltd.

• Founded in:

  2000-06-26

• Address:

  No. 1, Xianyao Road, Xianju County, Taizhou City, Zhejiang Province

• Tax NO.:

  913300007047892221

• Registered Funds:

  989.204866 million yuan

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