Finasteride is a synthetic steroid compound that is a specific inhibitor of the intracellular enzyme type II 5α-reductase in the process of metabolizing the androgen testosterone into dihydrotestosterone. Finasteride has no affinity for androgen receptors and has no androgenic, anti-androgenic, estrogen-like, anti-estrogen-like or progestational effects. Inhibition of this enzyme can hinder the conversion of testosterone to the androgen dihydrotestosterone in peripheral tissues, significantly reducing the concentration of dihydrotestosterone in serum and tissues. Compared with placebo, it can increase the level of testosterone in the blood circulation by about 10-15%, but it is still within the physiological range. Finasteride can rapidly reduce the concentration of dihydrotestosterone in serum and significantly reduce it within 24 hours after administration. Administration of finasteride can reduce the concentration of dihydrotestosterone in the scalp and serum of these patients. Men who are congenitally deficient in type II 5α-reductase will not suffer from male baldness. These data and the results of clinical studies confirm that finasteride can inhibit the shrinkage of scalp hair follicles and reverse the process of hair loss.

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