Compound clotrimazole cream (Ⅱ)

The clotrimazole contained in this product is an antifungal drug that has an inhibitory effect on dermatophytes such as Candida albicans. Urea can enhance the hydration of the stratum corneum, make the skin soft, and has antibacterial and antipruritic effects. The two have a synergistic effect.

The main ingredients of this product are betamethasone dipropionate, clotrimazole and gentamicin sulfate. Chemical name: 16-methyl-11,17,21-trihydroxy-9-fluoropregnane-1,4-diene-3,20-dione-17,21-dipropionate. Molecular weight: C28H37FO7

The product is a white cream with a fragrant smell and a cooling feeling.

Used for fungal diseases such as tinea manuum, tinea pedis, tinea cruris, tinea corporis and tinea versicolor.

For topical use: Take an appropriate amount of this product and apply it to the affected area, 2 to 3 times a day.

1. Adverse reactions that may occur occasionally with the use of compound clotrimazole include: paresthesia, maculopapular rash, edema, secondary infection, etc. 2. Adverse reactions that may occur with the use of clotrimazole include: erythema, stinging, blisters, desquamation, edema, urticaria and skin irritation. 3. Adverse reactions caused by topical use of corticosteroids include: burning sensation, allergic prurigo, dry skin, folliculitis, hirsutism, acne-like rash, hypopigmentation, perioral inflammation, allergic contact dermatitis, skin infiltration, secondary infection, skin atrophic striae and miliaria, etc. 4. There have been reports of adverse reactions such as thalamus-pituitary-adrenal (HPA) function suppression, Cushing's syndrome, and intracranial hypertension when topical use of corticosteroids in children. Adrenal suppression is manifested as linear growth inhibition, delayed weight gain, low plasma adrenaline levels, and disappearance of ACTH stress response; intracranial hypertension is manifested as forehead protrusion, headache and bilateral papilledema.

This product is contraindicated for patients who are allergic to any of the components of this product or to corticosteroids or imidazoles.

Precautions for children: Due to the relatively large body surface area of children, it is easy to increase the systemic absorption of drugs. When using this product, the sensitivity to adrenocortical hormone suppression and exogenous corticosteroid drugs is greater than that of adults. It has been reported that children have adverse reactions such as hypothalamic-pituitary-adrenal (HPA) function suppression, Cushing's syndrome, linear growth inhibition, delayed weight gain and intracranial hypertension when using local corticosteroid drugs. Adrenal suppression is manifested by low plasma adrenaline levels and disappearance of ACTH stress response. Intracranial hypertension is manifested by forehead protrusion, headache and bilateral papilledema. Precautions for pregnancy and lactation: There is no safety research data for this product for pregnant women. Pregnant women should consider the pros and cons of medication when using this product. If this product must be used, it is required not to use it for a long time or over a large area. It is not clear whether the topical use of corticosteroids increases the detectable amount of systemic absorption and excretion from breast milk. If lactating women use this product, they should stop taking the drug or stop breastfeeding. Precautions for the elderly: There is currently a lack of detailed research data.

If used with other drugs, drug interactions may occur. Please consult your doctor or pharmacist for details.

Sealed in a cool, dry place.

Each gram of cream contains 0.64 mg of betamethasone dipropionate (equivalent to 0.5 mg of betamethasone), 10 mg of clotrimazole, and 1.0 mg of gentamicin sulfate (calculated as gentamicin).

24 months