Methyldopa tablets

1 Methyldopa is an inhibitor of aromatic amino acid decarboxylase. 2 Only the levorotatory isomer of α-methyldopa has antihypertensive activity in humans, and the racemic form (DL-α-methyldopa) requires twice the dose to achieve the same antihypertensive effect. Its antihypertensive effect may be through its active metabolite α-methylnorepinephrine stimulating central inhibitory α-adrenergic receptors and pseudo-neurotransmitters, reducing plasma renin activity, and thus lowering arterial blood pressure. 3 Methyldopa can reduce the concentrations of serotonin, dopamine, norepinephrine, and methylepinephrine in tissues. 4 Methyldopa has no direct effect on cardiac function, and usually does not reduce glomerular filtration rate or renal blood flow.

The chemical name of this product is: L-3-(3,4-dihydroxyphenyl)-2-methylalanine sesquihydrate

This product is a sugar-coated tablet, which appears white after removing the sugar coating

hypertension.

1 Common dosage for adults: Oral, 250 mg/time, divided into 2~3 times/day. Adjust the dosage once every 2 days to achieve the desired therapeutic effect. Generally increase the dosage at night to reduce the excessive sedative effect of the drug. If used in combination with thiazide diuretics, the dosage needs to be reduced, and the initial dose is controlled at 500 mg/day, but the diuretic dose can remain unchanged. The maintenance dose is 0.5-2g/day, divided into 2-4 times orally, and the maximum dose should not exceed 3g/day. Because methyldopa has a short duration of action, other antihypertensive treatments must be given within 48 hours after discontinuation of the drug. Drug resistance may develop after 2-3 months of use, and diuretics can restore the therapeutic effect. 2 Common dosage for children: Oral, 10 mg/Kg per day, or 300 mg/m2 per body surface area, divided into 2~4 times orally. Adjust the dosage every 2 days.

1. Sedation, headache and fatigue occur more often when starting the medication and increasing the dosage, and are usually transient. 2. The more common ones are: lower limb edema and dry mouth caused by water and sodium retention. 3. Less common ones are: drug fever or eosinophilia, changes in liver function (possibly immune or allergic), mental changes (depression or anxiety, sleep talking, insomnia), decreased sexual function, diarrhea, breast enlargement, nausea, vomiting, and fainting. 4. Occasionally aggravate angina pectoris and heart failure. 5. Rare ones are: prolonged carotid sinus sensitivity and postural hypotension, weight gain, sinus bradycardia, liver function damage, pancreatitis, colitis sialadenitis, tongue pain or black tongue,

1. Active liver disease, such as acute hepatitis and active cirrhosis. 2. Positive direct antiglobulin (Coombs) test.

Precautions for children: follow doctor's advice. Precautions for pregnancy and lactation: follow doctor's advice. Precautions for the elderly: follow doctor's advice.

1 This product can increase the effect of oral anticoagulants. 2 This product can enhance the effect of central nervous system depressants. 3 Tricyclic antidepressants, sympathomimetic amines and non-steroidal anti-inflammatory analgesics can weaken the antihypertensive effect of this product. 4 This product can increase the blood prolactin concentration and interfere with the effect of bromocriptine. 5 It has a synergistic effect when used in combination with other antihypertensive drugs. 6 It can enhance the central nervous system toxicity when used in combination with levodopa. 7 The dose of anesthetics must be reduced when used in combination with anesthetics. 8 When used in combination with lithium, the toxic effects of lithium must be prevented.

Shade from light, store in a sealed container

0.25g

24 months

Hunan Er-Kang Pharmaceutical Co., Ltd.

• Founded in:

  2003-10-22

• Address:

  No. 167, Kangping Road, Liuyang Economic Development Zone, Changsha

• Tax NO.:

  914301007558022471

• Registered Funds:

  2,062,604,870 yuan

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