Mezlocillin Sodium and Sulbactam Sodium for Injection (4:1)

Pharmacological action: This product is a compound preparation of mezlocillin sodium and sulbactam sodium in a ratio of 4:1. Mezlocillin is a broad-spectrum penicillin antibiotic that mainly kills bacteria by interfering with the synthesis of bacterial cell walls; sulbactam has no antibacterial activity against other bacteria except Neisseriaceae and Acinetobacter, but sulbactam has an irreversible inhibitory effect on most important β-lactamases produced by β-lactam antibiotic-resistant strains. Sulbactam can prevent the destruction of penicillins and cephalosporins by resistant bacteria, and sulbactam has obvious synergistic effects with penicillins and cephalosporins. This product has a bactericidal effect on a variety of Gram-positive and Gram-negative bacteria (including aerobic and anaerobic strains), and is stable in vitro to β-lactamases produced by most bacteria.

This product is a compound preparation, whose components are: sterile powders of mezlocillin sodium and sulbactam sodium uniformly mixed, and the mixing ratio is mezlocillin: sulbactam is 4:1. The chemical name of mezlocillin sodium: (2S, 5R, 6R)-3,3-dimethyl-6{(R)-2{(3-(methylsulfonyl)-2-oxo-1-imidazolidine)carbonamide}-2-phenylacetamide}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate sodium

This product is white or off-white powder or crystalline powder.

This product contains β-lactamase inhibitor - sulbactam, which is suitable for the following moderate to severe infectious diseases caused by enzyme-producing resistant bacteria, including: 1 Respiratory system infections: such as otitis media, sinusitis, tonsillitis, pharyngitis, pneumonia, acute bronchitis and acute exacerbation of chronic bronchitis, bronchiectasis, empyema, lung abscess, etc.; 2 Urinary and reproductive system infections: such as pyelonephritis, cystitis and urethritis, etc.; 3 Abdominal infections: such as biliary tract infections, etc.; 4 Skin and soft tissue infections: such as cellulitis, wound infections, furunculosis, purulent dermatitis and impetigo; Sexually transmitted diseases: gonorrhea, etc.; 5 Pelvic infections: gynecological infections, postpartum infections, etc.; <br

Intravenous drip: Dissolve with appropriate amount of sterile water for injection or sodium chloride injection before use, then add 0.9% sodium chloride injection or 5% glucose sodium chloride injection or 5-10% glucose injection 100ml and drip intravenously, each drip time is 30-50 minutes. Adult dose: 3.75g each time (3.0g mezlocillin, 0.75g sulbactam), once every 8 hours or 12 hours, 7-14 days of treatment.

This product is usually well tolerated, and common adverse reactions are: 1. Gastrointestinal reactions: such as diarrhea, nausea, vomiting, etc. Diarrhea usually disappears during treatment or when the drug is no longer used. When severe and persistent diarrhea occurs, the possibility of potentially fatal antibiotic-induced low-membrane enterocolitis should be considered. At this time, the drug must be discontinued and appropriate treatment must be taken (such as oral vancomycin 4×250mg/day). Drugs that reduce motility are prohibited. 2. Allergic reactions: Occasionally allergic reactions occur, usually skin reactions (such as rash, itching). When urticaria occurs (urticaria reaction occurs when allergic to penicillin), the drug must be discontinued. Other penicillin anti-inflammatory drugs should not be continued for treatment. Others

It is contraindicated in patients who are allergic to penicillins or sulbactam.

When this product is used simultaneously with high-dose heparin and anticoagulants, coagulation parameters should be monitored. Probenecid can inhibit the renal excretion of this product. When using this product, the patient's non-enzymatic urine glucose reaction, urobilinogen test and urine protein determination may have false positive results. This product should be avoided in combination with drugs with strong acidity or alkalinity (below pH 4.0 or above pH 8.0).

Sealed, stored in a cool, dark and dry place, validity period: 2 years

Contains 2.0g of mezlocillin sodium (calculated as mezlocillin) and 0.5g of sulbactam sodium (calculated as sulbactam)

Shanxi Shuangyan Pharmaceutical Co., Ltd.

• Founded in:

  2004-06-18

• Address:

  Datong Development Zone Pharmaceutical Industrial Park

• Tax NO.:

  91140200762481795D

• Registered Funds:

  250 million yuan

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