Acyclovir for injection

Antiviral drug. It has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering the cells infected by herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cell kinase, and the drug is phosphorylated into activated acyclovir triphosphate, and then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase to inhibit viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. The carcinogenic and mutagenic effects of this product are still unclear. High-dose injection can cause testicular atrophy and reduced sperm count in animals. The drug can pass through the placenta, and animal experiments have confirmed that it has no effect on the embryo.

Acyclovir.

White loose lumps or powder.

Infections caused by herpes simplex virus and varicella-zoster virus, as well as herpes simplex, varicella and herpes zoster in immunocompromised patients.

Generally, a single dose of 5 mg/kg is intravenously dripped 3 times a day, dripped once every eight hours, and each drip time is more than 1 hour, and the drug is given continuously for 7 days. Preparation of injection: Dissolve each bottle (containing acyclovir 0.25) with 10 ml of injection water or normal saline, then add 100 ml of balance solution to dilute each bottle, and prepare it temporarily before use.

1. Allergic reaction: Sometimes allergic symptoms such as rash, urticaria, fever, etc. may occur, which will disappear after stopping the drug. 2. Nervous system: Rarely, there may be convulsions in the lower limbs, numbness of the tongue and hands and feet, tremors, and general fatigue. In this case, the dosage may be reduced or the drug may be discontinued, and appropriate treatment may be given. 3. Kidney: Sometimes, there may be an increase in blood urea nitrogen and serum creatinine values, proteinuria, and red blood cells and mucus in the urine sediment.

People who are allergic to this product are prohibited from using it. People with abnormal renal function, children and pregnant women should use it with caution.

Precautions for children: Although no special adverse reactions have been found in children, it should be used with caution. It is not advisable to prepare infusion solutions for newborns with diluents containing benzyl alcohol, otherwise it is easy to cause fatal syndromes, including acidosis, central nervous system depression, dyspnea, renal failure, hypotension, epilepsy and intracranial hemorrhage. Precautions for pregnancy and lactation: The drug can pass through the placenta. Although animal experiments have confirmed that it has no effect on the embryo, pregnant women still need to weigh the pros and cons when using it. The concentration of the drug in breast milk is 0.6 to 4.1 times the blood concentration. Although no abnormalities have been found in infants, lactating women should use it with caution. Precautions for the elderly: Due to the decline of physiological renal function, the dosage and medication interval of this product need to be adjusted.

1. When used intravenously with interferon or methotrexate (intrathecal), it may cause mental abnormalities and should be used with caution. 2. When used intravenously with nephrotoxic drugs, it can aggravate nephrotoxicity, especially in patients with renal insufficiency. 3. When used in combination with zidovudine, it can cause nephrotoxicity, manifested as deep lethargy and fatigue. 4. It competitively inhibits the secretion of organic acids with probenecid. The combined use of probenecid can slow down the excretion of this product, prolong the half-life, and cause drug accumulation in the body.

Keep away from light and store in sealed container.

0.25g

24 months

Hubei KEYI Pharmaceutical Industry Co., Ltd.

• Founded in:

  1997-05-23

• Address:

  No. 8, Huanglongshan South Road, East Lake New Technology Development Zone, Wuhan

• Tax NO.:

  91420000726103295U

• Registered Funds:

  34.750206 million yuan

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