Azathioprine Tablets

Almost all of it is converted into 6-mercaptopurine in the body to work. Because of its slow conversion process, it works slowly. It can inhibit Friend leukemia, inhibit virus infection in mice, inhibit spleen enlargement, and reduce the virus titer in the spleen and plasma. Rats injected intraperitoneally for 4 to 5 months showed weight loss, severe anemia and increased reticulocytes. When rabbits were given this drug in early pregnancy, it could cause teratogenesis, mainly affecting limb development. It can have an immunosuppressive effect by interfering with RNA metabolism. If a small dose is present in the culture medium for a long time, it can inhibit the killing cell effect of sensitized lymphocytes in vitro.

Each tablet contains 50 mg of azathioprine.

This product is light yellow tablet.

1. Acute and chronic leukemia. It has a better short-term effect on chronic myeloid leukemia and works quickly, but the remission period is short. 2. Acquired hemolytic anemia, idiopathic thrombocytopenic purpura, systemic lupus erythematosus. 3. Chronic rheumatoid arthritis, chronic active hepatitis (hepatitis related to autoimmunity), primary biliary cirrhosis. 4. Hyperthyroidism, myasthenia gravis. 5. Others: chronic nonspecific ulcerative colitis, segmental enteritis, polyradiculitis, lupus nephritis, proliferative nephritis, Wegener's granulomatosis, etc.

1. Oral administration: 1.5 mg ~ 4 mg/kg per day, once a day or divided into several times. 2. For allogeneic transplantation, 2 mg ~ 5 mg/kg per day, once a day or divided into several times. 3. For leukemia, 1.5 mg ~ 3 mg/kg per day, once a day or divided into several times.

It is similar to mercaptopurine but slightly less toxic. It can cause bone marrow suppression, liver damage, teratogenesis, skin rash, and occasionally muscle atrophy.

Patients with known hypersensitivity to this product are contraindicated.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: It can cause teratogenesis, pregnant women should not use it. Precautions for the elderly: It is not clear yet.

Allopurinol can inhibit the metabolism of mercaptopurine (the latter is the active metabolite of thiopurine) into inactive products, resulting in increased toxicity of mercaptopurine. When the two must be taken at the same time, the dose of thiopurine should be greatly reduced. Thiopurine can reduce the inactivation rate of 6-mercaptopurine, which is inactivated by the following ways: enzyme S-methylation, enzyme-independent oxidation, or conversion to thiourate by xanthine oxidase, etc. Thiopurine can react with sulfhydryl compounds such as glutathione, slowly releasing 6-mercaptopurine in tissues and acting as a prodrug.

Keep away from light and store in sealed container.

50 mg

24 months.

Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

• Founded in:

  1993-10-23

• Address:

  No. 905, Xinjinqiao Road, China (Shanghai) Pilot Free Trade Zone

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  91310000133742534B

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  1,191,611,312 yuan

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