Erythromycin Enteric-coated Tablets

Erythromycin is a macrolide antibiotic, which has antibacterial activity against Staphylococcus, various groups of Streptococcus and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. Erythromycin is only effective against bacteria with active division. This product is of low toxicity. In the acute toxicity test on mice, the oral lethal dose (LD50) was 2.93-3.11 g/kg; and in the oral test on rats, it was 3 g/kg.

Erythromycin

This product is an enteric-coated tablet, which appears white or off-white after removing the coating.

1 This product is used as an alternative to penicillin-allergic patients to treat the following infections: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc. 2 Legionnaires' disease. 3 Mycoplasma pneumonia. 4 Chlamydia pneumoniae pneumonia. 5 Urinary and reproductive system infections caused by other Chlamydia and Mycoplasma genera. 6 Chlamydia trachomatis conjunctivitis. 7 Gonorrhea infection. 8 Oral infection caused by anaerobic bacteria. 9 Campylobacter jejuni enteritis. 10 Whooping cough. 11 Recurrent rheumatic fever, infective endocarditis (after rheumatic heart disease, congenital heart disease, heart valve replacement surgery), oral, upper respiratory tract infection.

Oral administration: 0.75-2g per day for adults, divided into 3-4 times; 20-40mg/kg per day for children, divided into 3-4 times. For the treatment of Legionnaires' disease, 0.5-1.0g per time, 4 times a day for adults. When used as a preventive medication for recurrent rheumatic fever, 0.25g per time, 2 times a day. When used as a preventive medication for infective endocarditis, 1g is taken orally 1 hour before surgery, and 0.5g is taken 6 hours after surgery.

1 Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, decreased appetite, etc., and the incidence is related to the dose. 2 Hepatotoxicity is rare. Patients may experience fatigue, nausea, vomiting, abdominal pain, fever, abnormal liver function, and occasionally jaundice. 3 When used in large doses (ge; 4g/day), especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to excessive blood drug concentration (12mg/L), and most of them can be recovered after stopping the drug. 4 Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5 Others, occasionally arrhythmias, oral or vaginal candidiasis.

It is contraindicated for patients who are allergic to erythromycin.

Precautions for children: Precautions for pregnancy and lactation: This product can enter the fetal circulation through the placenta barrier, so pregnant women should use it with caution. A considerable amount of this product enters breast milk, so lactating women should use it with caution or stop breastfeeding. Precautions for the elderly:

1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. It has an antagonistic effect on chloramphenicol and lincomycin, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent that can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used at the same time. 4. Patients who take warfarin for a long time can prolong the prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5Except for dihydroxypropylphylline, simultaneous use with xanthine drugs can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the peak blood concentration of this product. Therefore, the dose of xanthine drugs should be adjusted during and after the combined treatment of the two. 6Combination with other hepatotoxic drugs may enhance hepatotoxicity. 7High doses of this product combined with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8When used in combination with lovastatin, its metabolism can be inhibited and blood concentrations can be increased, which may cause rhabdomyolysis; when used in combination with midazolam or triazolam, the clearance of the two can be reduced and their effects can be enhanced. 9This product can obstruct the enterohepatic circulation of sex hormones, and combined with oral contraceptives can reduce their efficacy.

Sealed, store in a dry place.

0.125 g (125,000 units)

36 months.

Henan Life Pharmaceutical Co., Ltd.

• Founded in:

  2008-02-22

• Address:

  Room 803, Nanyang Zhongguancun Information Valley Innovation Center, Jianhe Road, Nanyang High-tech Zone, Nanyang City, Henan Province

• Tax NO.:

  9141130074070920XE

• Registered Funds:

  17.25 million yuan

• Email:

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