Loxoprofen Sodium Tablets

Loxoprofen sodium is a prodrug that is converted into active metabolites in the body after being absorbed through the digestive tract. Its active metabolites exert analgesic, anti-inflammatory and antipyretic effects by inhibiting the synthesis of prostaglandins.

Chemical name: Sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate Molecular formula: C15H17NaO3·2H2O Molecular weight: 304.32

This product is a film-coated tablet, which appears white or off-white after removing the coating.

Rheumatoid arthritis, osteoarthritis, low back pain, frozen shoulder, cervical shoulder-wrist syndrome, as well as analgesia and anti-inflammation after surgery, trauma and tooth extraction, and antipyretic and analgesic for acute upper respiratory tract inflammation.

Oral administration after meals. Chronic inflammatory pain: Adults take 60 mg (1 tablet) each time, three times a day. Acute inflammatory pain: Take 60-120 mg (1-2 tablets) at once. The dosage can be increased or decreased according to age and symptoms, and the maximum daily dosage should not exceed 180 mg (3 tablets).

Loxoprofen sodium is a prodrug. It has no irritation to the gastrointestinal tract before being absorbed into the blood, and has no obvious therapeutic effect. It only works after being absorbed into the blood and converted into active metabolites. Therefore, it has no obvious irritation to the gastrointestinal tract, has good tolerance, and has low side effects. Digestive system discomfort is more common, such as abdominal pain, stomach discomfort, nausea, vomiting, loss of appetite, constipation, heartburn, etc., sometimes there will be rash, itching, edema, drowsiness, headache, palpitations, etc., occasionally shock, acute renal insufficiency, nephrotic syndrome, interstitial pneumonia, anemia, leukopenia, thrombocytopenia, eosinophilia, and elevated AST, ALT, ALP, etc.

The following patients are contraindicated to use this product: 1. Patients who are known to be allergic to this product. 2. Patients who have asthma, urticaria or allergic reactions after taking aspirin or other non-steroidal anti-inflammatory drugs. 3. Contraindicated for the treatment of perioperative pain during coronary artery bypass grafting (CABG). 4. Patients with a history of gastrointestinal bleeding or perforation after the use of non-steroidal anti-inflammatory drugs. 5. Patients with active gastrointestinal ulcers/bleeding, or patients with recurrent ulcers/bleeding in the past. 6. Patients with severe heart failure. 7. Patients with severe liver and kidney damage. 8. Patients with severe hematological abnormalities. 9. Women in late pregnancy and lactation.

Precautions for children: The safety of medication for children is not yet clear. Precautions for pregnancy and lactation: 1. The safety of medication during pregnancy has not yet been determined. Therefore, when treating pregnant or potentially pregnant women, medication should only be given when the benefits of treatment outweigh the risks. 2. Animal experiments have reported delayed delivery and migration into breast milk, leading to contraction of the fetal arterial tube. Therefore, do not give medication in late pregnancy and during lactation. Precautions for the elderly: This product is safer for the elderly, but it should still be started at a small dose, and the patient's condition should be closely observed and medication should be given with caution.

1. When this product is used simultaneously with coumarin anticoagulants and sulfonylurea hypoglycemic drugs, the effects of these drugs will be increased, and these drugs should be used in reduced doses. 2. When used in combination with new quinolone antibacterial drugs (enoxacin, etc.), it may sometimes cause cramps. 3. When used in combination with sulfonylurea hypoglycemic drugs, it can enhance the hypoglycemic effect of these drugs, and attention should be paid to reducing the dose. 4. When used in combination with thiazide diuretics, it can weaken the diuretic hypotensive effect of these drugs. 5. When used in combination with lithium preparations, it may increase the lithium concentration in the blood and cause lithium poisoning, and the dose should be reduced when used in combination.

Sealed and stored in a dry place.

60mg (calculated as C15H17NaO3)

Tentatively 24 months.

Disha Pharmaceutical Group Co., Ltd.

• Founded in:

  1997-04-30

• Address:

  No. 1-4, Qingdao South Road, Weihai Economic and Technological Zone

• Tax NO.:

  913710007062493501

• Registered Funds:

  599.7706277 yuan

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