Chewable Aspirin Tablets

Pharmacology: 1. Analgesic effect: It is mainly through inhibiting the synthesis of prostaglandins and other substances that can make pain sensitive to mechanical or chemical stimulation (such as bradykinin, histamine), and it is a peripheral analgesic. However, the possibility of central analgesia (possibly acting on the hypothalamus) cannot be ruled out; 2. Antipyretic effect: It may act on the hypothalamic temperature regulation center to cause peripheral vasodilation, increased skin blood flow, sweating, and increased heat dissipation to have an antipyretic effect. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus; 3. Inhibition of platelet aggregation: It works by inhibiting platelet cyclooxygenase and reducing the production of prostaglandins. Toxicology: Acute toxicity test: The LD50 of oral administration to rats is 1500mg/kg; the LD50 of oral administration to mice is 1100mg/kg.

The main ingredients of this product are: Aspirin

This product is white flakes, which may deteriorate easily when exposed to moisture.

1. This product has the effect of inhibiting platelet aggregation and can be used to prevent transient cerebral ischemic attack, myocardial infarction or thrombosis after other operations. 2. It is used to relieve mild or moderate pain, such as headache and toothache. 3. It is used to relieve fever and sore throat caused by colds.

Put the tablet in your mouth, chew it thoroughly, and take it with water. Children must take the medicine under the guidance of an adult. 1 Aspirin is used to inhibit platelet aggregation: Start with a small dose: once a day, one tablet at a time. Or adjust the dose as prescribed by a doctor. 2 It is used to relieve mild or moderate pain and fever and sore throat caused by colds. The dose should be adjusted according to age and weight. Please follow the doctor's advice.

Generally, the doses used for antipyretics and analgesia rarely cause adverse reactions. Long-term and large-scale use of the drug, especially when the blood concentration of the drug is >200mu;g/ml, is more likely to cause adverse reactions. The higher the blood concentration, the more obvious the adverse reactions: 1. The more common gastrointestinal reactions (incidence rate 3%~9%) include nausea, vomiting, upper abdominal discomfort or pain (caused by the direct stimulation of the gastric mucosa by this product), which usually disappear after stopping the drug. Long-term or large-dose use may cause gastrointestinal bleeding or ulcers; 2. Central nervous system: reversible tinnitus and hearing loss occur, which usually occur after a certain course of treatment and the blood concentration reaches 200~300mu;g/L; 3. Allergic reaction: occurs in 0.2% of patients, manifested as asthma, urticaria, angioedema or shock. Most of them are susceptible people, and taking

1. Patients who are allergic to this product are prohibited from using it. 2. Patients who are prohibited from using this product are prohibited from using it in the following situations: ① Active ulcer disease or gastrointestinal bleeding caused by other reasons; ② Hemophilia or thrombocytopenia; ③ Patients with a history of allergy to aspirin or other non-steroidal anti-inflammatory drugs, especially those with asthma, neuroangioedema or shock.

Precautions for children: Pediatric patients, especially those with fever and dehydration, are prone to toxic reactions. Acute febrile diseases, especially the use of this product in children with influenza and chickenpox, may be related to the occurrence of Reye's syndrome, which is still rare in China. Children should be cautious when using this product and take it according to the doctor's instructions. Precautions for pregnancy and lactation: This product easily passes through the placenta. Animal experiments show that the use of this product in the first 3 months of pregnancy can cause teratogenesis, such as spina bifida, skull cleft, facial cleft, leg deformity, and incomplete development of the central nervous system, internal organs and bones. There are also reports of fetal defects in humans after using this product. Aspirin can be excreted in breast milk. If a lactating woman takes 650 mg orally, the drug concentration in breast milk can reach 173-483μg/ml after 5-8 hours. Therefore, pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients are prone to toxic reactions due to decreased renal function when taking this product, so use it with caution in elderly patients.

1. The efficacy is not enhanced when used with other non-steroidal anti-inflammatory analgesics, because this product can reduce the bioavailability of other non-steroidal anti-inflammatory drugs. In addition, gastrointestinal side effects (including ulcers and bleeding) are increased; in addition, due to the enhanced inhibitory effect on platelet aggregation, the risk of bleeding in other parts may also be increased. Long-term and large-scale use of this product with acetaminophen may cause kidney diseases including renal papillary necrosis, renal cancer or bladder cancer; 2. When used with any drug that can cause hypoprothrombinemia, thrombocytopenia, reduced platelet aggregation function or gastrointestinal ulcer bleeding, there may be a risk of aggravating coagulation disorders and causing bleeding; 3. When used with anticoagulants (dicoumarol, heparin, etc.) and thrombolytics (streptokinase, urokinase), the risk of bleeding may be increased; 4. Urine alkalinizing drugs (sodium bicarbonate, etc.) and antacids (long-term and large-scale use) can increase the excretion of this product in urine and reduce the blood drug concentration. However, when the blood concentration of this product has reached a stable state and the alkaline drug is discontinued, the blood concentration of this product can be increased to a toxic level. Carbonic anhydrase inhibitors can alkalinize urine, but can cause metabolic acidosis. Not only can it reduce the blood concentration, but it can also increase the amount of this product that penetrates into the brain tissue, thereby increasing toxic reactions; 5 Uric acid drugs can reduce the excretion of this product and increase its blood concentration. Patients whose blood concentration of this product has reached a stable state may increase the blood concentration of this product and increase toxic reactions after adding uricidification drugs; 6 Glucocorticoids (hormones for short) can increase the excretion of salicylates. In order to maintain the blood concentration of this product when used together, the dose of this product should be increased if necessary. Long-term use of this product and hormones, especially when used in large quantities, increases the risk of gastrointestinal ulcers and bleeding. Therefore, it is not recommended to use these two drugs at the same time in clinical practice; 7 The hypoglycemic effect of insulin or oral hypoglycemic drugs can be enhanced and accelerated by using this product together; 8 When used together with methotrexate (MTX), it can reduce the binding of methotrexate to protein, reduce its excretion from the kidneys, increase the blood concentration and increase the toxic reaction; 9 The uric acid excretion effect of probenecid or sulfinpyrazone can be reduced by using this product at the same time; when the blood concentration of salicylate is 50ug/ml, it is significantly reduced, and it is even worse when it is 100-150ug/ml. In addition, probenecid can reduce the clearance rate of salicylate from the kidneys, thereby increasing the latter's blood concentration.

Sealed, store in a dry place.

75mg

24 months

Chifeng Mysun Pharmaceutical Co., Ltd.

• Founded in:

  2001-11-28

• Address:

  No. 1, Mengxin Street, Hongshan Economic Development Zone, Chifeng

• Tax NO.:

  91150402114795518Q

• Registered Funds:

  44.22 million yuan

• Email:

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