Sultamicillin Tosirate Capsules

Sultamicillin is a tosylate of sultamicillin synthesized by esterification of the beta-lactamase inhibitor sulbactam and the beta-lactam antibiotic ampicillin. It is a new oral antibiotic resistant to beta-lactamase. The enzyme inhibition of sulbactam can protect ampicillin from the destruction of B-lactamase secreted by resistant bacteria, thereby improving the antibacterial activity of ampicillin and making it an acid-resistant and enzyme-resistant high-efficiency antibiotic. The efficacy is 4-8 times stronger than ampicillin. It is effective against infections caused by ampicillin-resistant bacteria. Ampicillin is the bactericidal component of this product. It acts on the active reproduction stage of bacteria and has a bactericidal effect by inhibiting the synthesis of bacterial cell wall mucopeptides. Sulbactam is a competitive irreversible B-lactamase inhibitor. It is used in combination with ampicillin to synergize its antibacterial effect. After oral administration, this product is hydrolyzed into sulbactam and ampicillin by enterolactone in the intestinal wall. The bioavailability is 80% of that of intravenous injection. Taking it after meals does not affect its absorption. 50%-75% of this product is excreted in the urine in the original form.

The main ingredient of this product is sultamicillin tosylate, and its chemical name is () Hydroxymethyl-(2S,5R,6R)-6[(R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxido-4-thia-1-azabicyclo[3,2,0]n-heptane-2-carboxylate, 2S,5R-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]n-heptane-2-carboxylate.

This product is a capsule, and the contents are white or slightly yellow granules or powder.

This product is suitable for the treatment of the following infections caused by sensitive bacteria: 1. Upper respiratory tract infections: sinusitis, otitis media, tonsillitis, etc. 2. Lower respiratory tract infections: bronchitis, pneumonia, etc. 3. Urinary tract infections and pyelonephritis. 4. Skin and soft tissue infections. 5. Gonorrhea.

Oral administration: 375 mg (3 capsules) for adults (including the elderly) and children weighing more than or equal to 30 grams, twice a day, for a course of 5-14 days or as directed by a doctor. For any infection caused by hemolytic streptococci, the minimum course of treatment is 10 days. To prevent the occurrence of acute rheumatic fever or glomerulonephritis. When treating gonorrhea, a single dose of 2.25 g of this product can be taken orally, and probenecid can be added to prolong the serum concentration of ampicillin and sulbactam. When suspected of concurrent infection with Treponema pallidum, a dark field examination should be performed before using this product, and a serum test should be performed at least once a month within four months.

Generally, the reaction is mild to moderate and disappears naturally when the medication is continued. Adverse reactions related to taking ampicillin are expected to occur occasionally. Occasionally: 1. Gastrointestinal reactions, such as diarrhea, loose stools, nausea, abdominal pain, cramps, upper abdominal pain and vomiting. 2. Rash and itching. 3. Others: such as drowsiness, sedation, fatigue, discomfort and headache.

It is contraindicated for patients who are allergic to penicillins.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Since there is no safety data for pregnant and lactating women, pregnant and lactating women should use it with caution. Precautions for the elderly: Not yet clear.

Not yet clear.

Sealed, stored in a cool, dark and dry place.

0.125g (calculated as C25H30N409S2)

24 months

Hainan Sanye Pharmaceutical Factory Co., Ltd.

• Founded in:

  1989-01-19

• Address:

  No. 6, Sanye East Road, Longhua District, Haikou City, Hainan Province

• Tax NO.:

  914600002012496387

• Registered Funds:

  10 million yuan

• Email:

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