Metronidazole

1. This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. 2. In vitro tests have shown that when the drug concentration is 1~2mg/L, the histolytica can undergo morphological changes in 6~20 hours and all are killed within 24 hours. The concentration of 0.2mg/L can kill the histolytica within 72 hours. 4. This product has a strong effect of killing trichomonas, and its mechanism is unknown. Metronidazole has a killing effect on anaerobic microorganisms. The metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death. It has a carcinogenic effect on some animals.

Metronidazole

This product is white or off-white tablets.

It has broad-spectrum anti-anaerobic and antiprotozoal effects and is mainly used clinically to prevent and treat infections caused by anaerobic bacteria, such as respiratory tract, digestive tract, abdominal and pelvic infections, infections of the skin, soft tissue, bones and joints, as well as endocarditis, brain abscess, sepsis and meningitis caused by Bacteroides fragilis. It is also widely used to prevent and treat oral anaerobic infections.

1. Common dosage for adults (1) For intestinal amebiasis, 0.4-0.6 g once, 3 times a day, for a course of 7 days; for extraintestinal amebiasis, 0.6-0.8 g once, 3 times a day, for a course of 20 days. (2) For giardiasis, 0.4 g once, 3 times a day, for a course of 5-10 days. (3) For dracunculiasis, 0.2 g once, for a course of 7 days. (4) For balantidiasis, 0.2 g once, 2 times a day, for a course of 5 days. (5) For cutaneous leishmaniasis, 0.2 g once, 4 times a day, for a course of 10 days. Repeat the course of treatment after an interval of 10 days. (6) For trichomoniasis, 0.2 g once, 4 times a day, for a course of 7 days; suppositories can be used at the same time, 0.5 g inserted into the vagina every night, for 7-10 days. (7) For anaerobic infections, take orally daily

Adverse reactions occur in 15-30% of cases, with digestive tract reactions being the most common, including nausea, vomiting, loss of appetite, and abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, occasional paresthesia, limb numbness, ataxia, multiple neuritis, etc., and high doses can cause convulsions. A small number of cases develop urticaria, flushing, itching, cystitis, dysuria, metallic taste in the mouth, and leukopenia, all of which are reversible and recover on their own after stopping the drug.

Contraindicated in patients with active central nervous system disorders and blood diseases

This product can enhance the effect of anticoagulants such as warfarin. When used in combination with oxytetracycline, it can interfere with the effect of metronidazole in clearing vaginal Trichomonas.

Keep in dark place and sealed

24 months

Wanbangde Pharmaceutical Group Co., Ltd.

• Founded in:

  2002-07-29

• Address:

  No. 28, Baizhang North Road, Chengdong Street, Wenling City, Taizhou City, Zhejiang Province

• Tax NO.:

  9133100074290886X3

• Registered Funds:

  360 million yuan

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