Calcium folinate tablets

This product is a formyl derivative of tetrahydrofolate, mainly used for the rescue of high-dose methotrexate and other folic acid antagonists. The main function of methotrexate is to bind to dihydrofolate reductase, blocking the conversion of dihydrofolate into tetrahydrofolate, thereby inhibiting DNA synthesis. After entering the body, this product is converted into tetrahydrofolate by tetrahydrofolate reductase, which can effectively counteract the toxic reaction caused by methotrexate, but has no obvious effect on the existing methotrexate neurotoxicity.

The main ingredient of this product is calcium folinate, and its chemical name is: N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pterydinyl)methyl]amino]benzoyl-L-glutamate calcium salt pentahydrate.

This product is slightly yellow or light yellow tablets.

1. Used as an antidote for folic acid antagonists (such as methotrexate, pyrimethoprim or trimethoprim). 2. Used to prevent severe toxic effects caused by overdose or high-dose treatment with methotrexate. 3. Also used to treat megaloblastic anemia caused by folic acid deficiency. 4. Used in combination with 5-fluorouracil for advanced colon and rectal cancer.

1 Oral administration of this product as a "rescue" therapy for methotrexate, the dosage is best determined based on the blood drug concentration. The commonly used dose is 5-15 mg, once every 6-8 hours, for 2 consecutive days. 2 As an antidote for pyrimethamine or trimethoprim, the daily dose is 5-15 mg, depending on the poisoning situation. 3 For anemia, take 15 mg orally daily. 4 When used in combination with 5-fluorouracil, take 20-30 mg/m2 orally, half an hour before taking 5-fluorouracil.

Rarely, allergic reactions such as rash, hives, or asthma may occur occasionally.

It is contraindicated in pernicious anemia and megaloblastic anemia caused by vitamin B12 deficiency.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

The main ingredient of this product is calcium folinate, and its chemical name is: N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pterydinyl)methyl]amino]benzoyl-L-glutamate calcium salt pentahydrate.

Keep away from light, seal tightly, and store in a cool place.

15mg (as folinic acid)

24 months

Shenzhen Zhonglian Pharmaceutical Co., Ltd.

• Founded in:

  1988-10-11

• Address:

  Room 401, Building 1, Block B, No. 9 Danqing Road, Jinsha Community, Kengzi Street, Pingshan District, Shenzhen (One license, multiple locations enterprise)

• Tax NO.:

  91440300192188676Y

• Registered Funds:

  120 million yuan

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