Norfloxacin Tablets

A broad-spectrum antibacterial drug that works on both Gram-positive and Gram-negative bacteria. Bacteria are not easy to develop resistance to this product, and there is no cross-resistance between similar drugs and antibiotics. It has strong antibacterial activity against Gram-negative bacteria, especially bacteria of the Enterobacteriaceae family, such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacter aerogenes, Serratia, Citrobacter, etc., which are highly sensitive to this product, and the minimum inhibitory concentration is generally less than 0.5mu;g/ml. Influenzae is also highly sensitive to this product. It also has an effect on Pseudomonas aeruginosa and other Pseudomonas, but requires a higher concentration, with a minimum inhibitory concentration of 4 to 32mu;g/ml; because the concentration of this product in urine exceeds the above concentration by several to more than ten times, it is still effective in treating Pseudomonas aeruginosa urinary tract infections. Among Gram-positive cocci, it is more sensitive to Staphylococcus aureus and Staphylococcus epidermidis, with the lowest concentration for 90% inhibition of bacteria being about 1-2 mu;g/ml, while the lowest concentration for 90% inhibition of enterococci and pneumococci is about 4 mu;g/ml and 16 mu;g/ml.

The main ingredient of this product is norfloxacin

This product is a sugar-coated tablet, which is light yellow after removing the sugar coating. It is relatively stable to light, heat and humidity.

It is suitable for acute and chronic pyelonephritis, cystitis, prostatitis, bacterial dysentery, cholecystitis, typhoid fever, pre- and postpartum infection, pelvic inflammatory disease, otitis media, sinusitis, acute tonsillitis and skin and soft tissue infection caused by sensitive bacteria. It can also be used as a preventive medicine for abdominal surgery.

Take orally on an empty stomach. Adults take 0.1-0.2g at a time, 3-4 times a day. For severe cases, increase the dosage as appropriate, 1.6g a day, divided into 4 times.

There may be upper abdominal discomfort in the early stage of medication, which generally does not require discontinuation and can gradually disappear on its own. However, patients with a history of gastric ulcer should use it with caution.

Patients who are allergic to this product and fluoroquinolones are contraindicated.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: Reproduction studies have been conducted on monkeys with doses as high as 10 times the human dose, and it was found that this product can cause abortion. The peak plasma concentration (Cmax) of this dose in monkeys is about twice that of humans. This product has not been proven to be teratogenic in animals. However, no appropriate and well-controlled studies have been conducted in pregnant women, so this product should not be used in pregnant women. There is a lack of information on whether this product is secreted through breast milk. When nursing women use 200 mg of this product, the drug cannot be detected in breast milk. However, due to the small study dose, and the fact that other types of drugs in this class are secreted through breast milk, coupled with the potential serious adverse reactions to newborns and infants, nursing women should avoid using this product or stop breastfeeding when using it. Precautions for the elderly: Elderly patients often have impaired renal function, and because this product is partially excreted through the kidneys, it needs to be used in a reduced dose.

1 Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2 When this product is used in combination with theophylline, competitive inhibition of the binding site of cytochrome P450 may lead to a significant reduction in the liver clearance of theophylline, a prolonged blood elimination half-life (t1/2), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 3 Cyclosporine combined with this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4 This product can enhance the anticoagulant effect of the latter when used with the anticoagulant warfarin. When used in combination, the patient's prothrombin time should be closely monitored. 5 Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, it may cause toxicity due to the increased blood concentration of this product. 6 This product has an antagonistic effect with nitrofurantoin and is not recommended for combined use. 7 Multivitamins, or other preparations containing iron or zinc ions, and antacids containing aluminum or magnesium can reduce the absorption of this product. It is recommended to avoid co-administration. If it cannot be avoided, take it 2 hours before or 6 hours after taking this product. 8 Didanosine can reduce the oral absorption of this product. Because its preparation contains aluminum and magnesium, it can chelate with fluoroquinolones, so it is not suitable for co-administration. 9 This product interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, prolonged blood elimination half-life (t1/2), and possible central nervous system toxicity.

Keep in a sealed container and away from light.

0.1g

24 months

Jiangxi Conba Traditional Chinese MEDICINE Co., Ltd.

• Founded in:

  2008-07-15

• Address:

  No. 1, Zhanwang Road, High-tech Park, Yiyang County, Shangrao City, Jiangxi Province

• Tax NO.:

  91361126677950534F

• Registered Funds:

  170 million yuan

• Email:

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