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Cefaclor Dry Suspension

Function and Efficacy

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

Ingredients

The main ingredient of this product is: Cefaclor.

Name Description Content CAS NO. Manufacturer
CefaclorIngredients

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

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Appearance

This product is a powder with flavoring.

Indication

This product is mainly suitable for respiratory system, urinary system, ENT, skin and soft tissue infections caused by sensitive bacteria.

Usage and Dosage

Oral administration. Adults: 0.25g once, 3 times a day. For patients with severe infection, the dose can be doubled, but the total amount per day should not exceed 4g. Or follow the doctor's advice. Children: 20-40mg/kg per day, divided into 3 doses, but the total amount per day should not exceed 1g.

Adverse Reactions

1. Common gastrointestinal reactions: soft stools, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, heating, etc. 2. Serum sickness-like reactions are more common than other antibiotics, especially in children, with typical symptoms including skin reactions and joint pain. 3. Allergic reactions: rash, urticaria, eosinophilia, vulvar itching, etc. 4. Others: mild increase in serum aminotransferase, urea nitrogen and creatinine, proteinuria, cystic urine, etc.

Precautions

Patients who are allergic to this product or other cephalosporins are contraindicated.

Special Population Medication

Precautions for children: The safety of the drug for newborns has not yet been determined. Precautions for pregnancy and lactation: 1. Pregnant women should use with caution. 2. This product can be excreted through breast milk, so lactating women should use it with caution or stop breastfeeding. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function under the guidance of a physician.

Drug Interactions

1. The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and nephrotoxic drugs such as aminoglycoside antibiotics with this product may increase nephrotoxicity. 2. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of β-lactamase. 3. Oral administration of probenecid can delay the excretion of this product.

Storage

Protect from light, seal tightly, and store in a cool and dry place.

Packaging Specification

Calculated as C15H14ClN3O4S 0.125g

Validity Period

24 months

Manufacturer

Shandong Yikang Pharmaceutical Co., Ltd.

  • Founded in:

    1999-01-26
  • Address:

    No. 3288, Yikang Avenue, Tengzhou City
  • Tax NO.:

    91370400169901867G
  • Registered Funds:

    34.56 million yuan
  • Website:

  • Email:

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