Pyrimethamine Tablets

1. Pyrimethamine has an inhibitory effect on the erythrozoite stage of some Plasmodium falciparum and Plasmodium vivax parasites, and its inhibitory effect on the erythrozoite stage is limited to the immature schizont stage, which can inhibit the division of trophozoites. 2. The erythrozoite stage of Plasmodium cannot utilize folic acid in the environment, but must synthesize it on its own. Pyrimethamine is an inhibitor of dihydrofolate reductase, which prevents dihydrofolate from being reduced to tetrahydrofolate, thereby affecting the biosynthesis of purine and pyrimidine nucleotides, and finally reducing nucleic acid synthesis, inhibiting the division of the cell nucleus and the reproduction of Plasmodium. 3. Plasmodium DNA synthesis mainly occurs in the trophozoite stage, and very little is synthesized in the schizont stage. Therefore, pyrimethamine mainly acts on Plasmodium undergoing schizont proliferation, and is ineffective against fully developed schizonts.

The chemical name of this product is: 6-ethyl-5-(4-chlorophenyl)-2,4-pyrimidinediamine. Molecular formula: C12H13ClN4 Molecular weight: 248.71

This product is white tablets.

This product is mainly used for the prevention of malaria and can also be used to treat toxoplasmosis.

1 Oral dosage for adults. ① For preventive medication, it should be taken 1 to 2 weeks before entering the epidemic area, and it is generally advisable to take it until 6 to 8 weeks after leaving the epidemic area, 4 tablets per week; ② For malignant malaria caused by chloroquine-resistant strains, 2 tablets per day, divided into 2 doses, and the course of treatment is 3 days; ③ For the treatment of toxoplasmosis, 50 to 100 mg per day, for 1 to 3 days (depending on tolerance), and then 25 mg per day, for a course of treatment of 4 to 6 weeks. 2 Oral dosage for children. ① For preventive medication, 0.9 mg/kg per day, once a week, the maximum dose is limited to the adult dose; ② For malignant malaria caused by chloroquine-resistant strains, 0.3 mg/kg per day, 3 times a day, and the course of treatment is 3 days; ③ For toxoplasmosis, 1 mg/kg per day, divided into 2 doses, and after taking it for 1 to 3 days, change to 0.5 mg/kg per day, divided into 2 doses, and the course of treatment is 4 to 6 weeks.

When taken orally at a general antimalarial therapeutic dose, the toxicity is very low and relatively safe. When used in large doses, such as 25 mg per day for more than one month, folic acid deficiency will occur. It mainly affects tissues that grow and reproduce particularly rapidly, such as bone marrow and digestive tract mucosa, causing hematopoietic function and digestive tract symptoms, such as changes or loss of taste, tongue pain, redness, swelling, burning and tingling, oral ulcers, leukoplakia, etc., dysphagia, nausea, vomiting, abdominal pain, diarrhea, etc. caused by esophagitis. More serious are megaloblastic anemia, leukopenia, etc., which can recover on their own if the drug is stopped early. Folic acid can improve bone marrow function. Skin erythema caused by allergies is less common.

1 Pregnant women are prohibited from using this product. Animal experiments have shown that this product can cause fetal malformations. 2 Lactating women are also prohibited from using this product because this product can be excreted through breast milk and interfere with the folic acid metabolism of infants. If the infant has glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, it can cause hemolytic anemia.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Not yet clear.

Keep away from light and store in sealed container.

6.25mg

24 months

Chongqing Dikang Changjiang Pharmaceutical Co., Ltd.

• Founded in:

  1998-10-23

• Address:

  No. 1, Longjinggou, Wanzhou District, Chongqing

• Tax NO.:

  91500101711601670G

• Registered Funds:

  50 million yuan

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