Domperidone orally disintegrating tablets

1. Pharmacological action: This product is a peripheral dopamine receptor antagonist, which can promote the peristalsis and tension of the upper gastrointestinal tract to return to normal, promote gastric emptying, increase the movement of the gastric antrum and duodenum, coordinate the contraction of the pylorus, and also enhance the peristalsis of the esophagus and the tension of the lower esophageal sphincter, inhibit nausea and vomiting, and do not affect the secretion of gastric juice. This product is not easy to pass through the blood-brain barrier and has almost no antagonistic effect on dopamine receptors in the brain. Therefore, it generally has no adverse reactions to the mental and central nervous systems. 2. Toxicity studies: Genetic toxicity: No evidence related to genetic mutations was found in the dominant lethal study of male and female mice, the micronucleus test of female mice and female rats, the chromosome abnormality study of human lymphocytes, the sex-linked recessive lethal test of fruit flies, and the Ames metabolic activity test of Salmonella typhi. 3. Carcinogenicity: In the carcinogenicity study in which mice were given the drug for 18 months and rats were given the drug for 24 months, an increased incidence of malignant breast tumors was found in female mice and rats when the dose was 25 times the maximum human dose, and an increased incidence of pituitary tumors was found in male rats when the dose was 25 times the human dose. There were no other dose-related effects.

The main ingredient is domperidone. Molecular weight: C22H24CLN5O2

This product is white tablets

Used for indigestion, abdominal distension, belching, nausea, vomiting, and abdominal pain.

Oral administration: Adults take 1 tablet each time, 3 times a day, 15 to 30 minutes before meals.

1. Occasionally, dry mouth, headache, insomnia, nervousness, dizziness, drowsiness, fatigue, abdominal cramps, diarrhea, reflux, nausea, heartburn, rash, itching, urticaria, stomatitis, conjunctivitis, etc. 2. Sometimes it leads to increased serum prolactin levels, galactorrhea, feminization of male breasts, and irregular menstruation in women, but it can return to normal after stopping the drug.

It is contraindicated for patients with mechanical obstruction, gastrointestinal bleeding, and gastrointestinal perforation.

Precautions for children: The metabolism and blood-brain barrier function of infants under 1 year old are not fully developed. The possibility of adverse central reactions cannot be ruled out when using it, so it should be used with caution. Close monitoring is required if used. Precautions for pregnancy and lactation: For pregnant women, this product should be used with caution only when the benefits of treatment outweigh the possible risks. Lactating women: This product can be excreted through breast milk and is not recommended for use by lactating women. Precautions for the elderly: The medication for elderly patients is the same as that for adults.

1. Anticholinergic drugs, such as acetaminophen, propantheline bromide, scopolamine, belladonna tablets, etc., will weaken the effect of this product and should not be taken at the same time. 2. When this product is used together with acetaminophen, ampicillin, levodopa, tetracycline, etc., the absorption rate of these drugs will increase. 3. Antacids and anti-secretory drugs will reduce the oral bioavailability of domperidone and should not be taken with this product at the same time. 4. Domperidone is mainly metabolized by the liver microsomal CYP3A4 enzyme. 5. Because domperidone has the effect of promoting gastric motility, it will theoretically affect the absorption of oral drugs used in combination, especially sustained-release or enteric-coated preparations. 6. Domperidone does not enhance the effect of neuroleptics; this product should not be used simultaneously with monoamine oxidase inhibitors (AMOI). 7. Domperidone will reduce dopaminergic

Keep away from light and tightly closed.

10 mg

24 months

Guangdong Reekon Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-08

• Address:

  Area A, 2nd Floor, 3rd Floor, 4th Floor, No. 3, Pingdong 5th Road, Nanping Science and Technology Industrial Park, Zhuhai

• Tax NO.:

  91440400617509085T

• Registered Funds:

  $2.1 million

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