Ticarcillin Sodium and Clavulanate Potassium for Injection

The main ingredients of Ticarcillin Sodium and Clavulanate Potassium for Injection are Ticarcillin Sodium and Clavulanate Potassium. Ticarcillin is a broad-spectrum bactericidal agent of the penicillin class, while clavulanic acid is an irreversible, highly effective β-lactamase inhibitor. Many Gram-positive bacteria (G) and Gram-negative bacteria (G-) can produce β-lactamases, which can destroy penicillins before they act on pathogens. Clavulanic acid restores ticarcillin sensitivity by blocking β-lactamase from destroying the bacterial defense barrier. Potassium clavulanate has little antibacterial effect alone, but when combined with Ticarcillin, this product becomes an antibiotic with a broad-spectrum bactericidal effect, which is suitable for the empirical treatment of a wide range of bacterial infectious diseases. This product is an antibiotic with a broad bactericidal effect, and its in vitro antibacterial spectrum is:

This product is a compound preparation, whose components are ticarcillin sodium and clavulanate potassium; calculated on the basis of effective acid, the ratio of ticarcillin sodium to clavulanate potassium is 15:1.

This product is white to light yellow powder with a peculiar odor.

This product is suitable for the treatment of various bacterial infections, and its scope of action is wide. The main indications are as follows: severe infection: sepsis, bacteremia, peritonitis, intra-abdominal sepsis, infection in special populations (secondary to immune system suppression or damage), postoperative infection, bone and joint infection, skin and soft tissue infection, respiratory tract infection, severe or complicated urinary tract infection (such as pyelonephritis), ear, nose and throat infection. This product has a synergistic effect when used in combination with aminoglycoside antibiotics to treat a variety of infections (including Pseudomonas aeruginosa infection), especially in the treatment of critical infections and infections in patients with low immune system function. When this product is used in combination with aminoglycoside antibiotics, the two drugs should be administered separately.

Dosage: Adults (including the elderly): Common dose: 1.6 g to 3.2 g every 6 to 8 hours, depending on body weight. Maximum dose: 3.2 g every 4 hours. Recommended dose for patients with renal insufficiency: 3.2 g every 8 hours for mild renal insufficiency (creatinine elimination rate>30 ml/min) 1.6 g every 8 hours for moderate renal insufficiency (creatinine elimination rate>10-30 ml/min) 1.6 g every 12 hours for severe renal insufficiency (creatinine elimination rate>10 ml/min) Children: Common dose: 80 mg/kg body weight every time, administered once every 6 to 8 hours.

Allergic reactions: If allergic reactions occur, the drug should be stopped immediately. Manifestations include rash, herpes, urticaria and other allergic reactions. Gastrointestinal reactions: nausea, vomiting and diarrhea. Pseudomembranous colitis is rare. Changes in liver function: moderate increase in AST and/or ALT. There are individual reports of hepatitis and cholestatic jaundice. The above changes can also occur with the use of other penicillins and cephalosporins. Changes in renal function: rare hypokalemia. Central nervous system reactions: rare convulsions, mainly occurring in patients with renal insufficiency or large doses of this product. Changes in the blood system: thrombocytopenia, leukopenia and bleeding phenomena. Local reactions: intravenous injection site

It is contraindicated for patients with a history of allergy to β-lactam antibiotics (such as penicillin, cephalosporin).

Probenecid can reduce the renal tubular secretion of ticarcillin, thereby delaying the renal excretion of ticarcillin, but does not affect the renal excretion of clavulanic acid.

Keep in a dark, airtight, cool place. Validity period: 12 months

1.6g (C15H16N2O6S21.5g and C8H9NO50.1g)

Zhengzhou Yugang Star Pharmaceutical Co., Ltd.

• Founded in:

  2017-11-08

• Address:

  South side of Chunqiu Road, Guandu Industrial Park, Zhongmou County, Zhengzhou

• Tax NO.:

  91410122MA44K1D7XY

• Registered Funds:

  7.93 million yuan

• Email:

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