Clarithromycin dry suspension

This product belongs to the macrolide antibiotics, and its mechanism is to inhibit protein synthesis by hindering the association of 50S subunits of nuclear proteins. This product has an inhibitory effect on Gram-positive bacteria, such as Staphylococcus aureus, Streptococcus, and Pneumococcus, and also has an inhibitory effect on some Gram-negative bacteria such as Haemophilus influenzae, Bordetella pertussis, Gonorrhea, Legionella pneumophila, and some anaerobic bacteria such as Bacteroides fragilis, Streptococcus peptostreptococcus, Propionibacterium acnes, etc., and also has an inhibitory effect on mycoplasma. The characteristics of this product are that its antibacterial activity in vitro is similar to that of erythromycin, but its antibacterial activity in vivo against some bacteria, such as Staphylococcus aureus, Streptococcus, and Haemophilus influenzae, is stronger than erythromycin. There is cross-resistance between this product and erythromycin.

Clarithromycin.

This product is a mixture of white or off-white coated micropellets and powdered suspending agents with a fragrant aroma and sweet taste.

This product is suitable for the following infections caused by clarithromycin-sensitive bacteria: nasopharyngeal infections (including tonsillitis, pharyngitis, sinusitis), lower respiratory tract infections (including bronchitis, bacterial pneumonia, atypical pneumonia), skin infections (including impetigo, erysipelas, folliculitis, furunculosis and wound infections).

Oral administration: Put this product into appropriate amount of warm water, stir evenly and then take orally. The usual dosage for adults is 0.25g once, once every 12 hours. For patients with severe infection, take 0.5g once, once every 12 hours. For children, take 10-15mg/kg per day according to body weight, divided into 2-3 doses. Or follow the doctor's advice.

1. After taking clarithromycin orally, you may experience gastrointestinal discomfort (such as nausea, heartburn, abdominal pain or diarrhea), headache and rash. Aminotransferase may increase temporarily, but it will return to normal after stopping the drug. 2. Allergic reactions may occur, ranging from drug rash and urticaria in mild cases to anaphylactic shock in severe cases.

1. Patients who are allergic to this product or macrolide drugs or have severe liver dysfunction are prohibited from using this product. 2. Patients with arrhythmia, bradycardia, prolonged Q-T interval, ischemic heart disease, congestive heart failure, etc. 3. Patients with water and electrolyte disorders. 4. Patients taking terfenadine.

Precautions for children: It is recommended to use clarithromycin dry suspension or granules. Precautions for pregnancy and lactation: The safety of clarithromycin for pregnant and lactating women has not been confirmed. Clarithromycin can be excreted in breast milk. Precautions for the elderly: See [Pharmacokinetics] for elderly patients.

1. Clarithromycin can interfere with the blood concentration of carbamazepine. The dosage of carbamazepine should be adjusted for patients taking both drugs together. 2. Clarithromycin can slightly increase the blood concentration of theophylline, but the dosage of theophylline does not need to be adjusted. 3. Like other macrolides, it can interact with warfarin or cyclosporine. 4. It has been reported that macrolide antibiotics can change the metabolism of terfenadine, causing its concentration to increase and induce arrhythmias.

Sealed, store in a cool, dry place.

0.125g (125,000 units), 0.25g (250,000 units)

Tentative 24 months

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

• Founded in:

  1992-12-31

• Address:

  No. 866, Moganshan Road, Gongshu District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100609120774J

• Registered Funds:

  872.30813 million yuan

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