Levothyroxine Sodium

This product is a synthetic sodium tetraiodothyronine, which is converted into triiodothyronine in the body and its activity is enhanced. It has the effects of maintaining normal growth and development of the human body, promoting metabolism, increasing heat production and enhancing sympathetic function. Studies using 131I-labeled sodium levothyroxine have shown that the serum T1/2 is 7 days and that in tissues is 0.4 days. The drug efficacy can be maintained for several weeks after drug withdrawal. After oral administration, it is absorbed by an average of 50%. It is mainly metabolized in the liver and most of it is excreted in the urine.

This product is white tablets

It is suitable for long-term replacement treatment of congenital hypothyroidism (cretinism) and hypothyroidism caused by various reasons in children and adults. It can also be used for suppression (and replacement) treatment of simple goiter, chronic lymphocytic thyroiditis, and thyroid cancer surgery. It can also be used for suppression tests to diagnose hyperthyroidism.

Oral administration for adults: Generally, the initial daily dose is 25-50 μg, and the maximum dose does not exceed 100 μg. The dose can be increased by 25-50 μg every 2-4 weeks until normal metabolism is maintained. The general maintenance dose is 50-200 μg/day. Elderly patients or patients with cardiovascular diseases: The initial dose is 12.5-25 μg, and the dose can be increased every 3-4 weeks, with an increase of 12.5-25 μg each time. After taking the medicine, the patient should be closely observed for increased heart rate, arrhythmia, changes in blood pressure, and regular monitoring of thyroid hormone levels. If necessary, the dose should be temporarily increased or reduced.

Symptoms of overdose include angina pectoris, arrhythmia, palpitations, diarrhea, vomiting, tremor, excitement, headache, restlessness, insomnia, sweating, hot flashes, weight loss, skeletal muscle cramps, etc. These symptoms usually disappear after reducing the dosage or stopping the drug for a few days.

It is contraindicated for patients with non-hypothyroid heart failure, tachyarrhythmias, recent myocardial infarction, and those who are allergic to this drug.

1. Levothyroxine sodium will increase the effect of anticoagulants; 2. Levothyroxine sodium will increase the level of phenytoin sodium in the blood; 3. Anticonvulsants such as carbamazepine and phenytoin sodium accelerate the metabolism of levothyroxine sodium and displace thyroxine from plasma proteins; 4. This product is used together with cardiac glycosides, and the dosage of cardiac glycosides must be adjusted accordingly; 5. Levothyroxine sodium will also increase the effect of sympathomimetic drugs; 6. Levothyroxine sodium increases the sensitivity of catecholamine receptors, thereby enhancing the effect of tricyclic antidepressants; 7. Cholestyramine reduces the absorption of levothyroxine sodium, and the use of oral contraceptives at the same time requires an increase in the dosage of levothyroxine sodium.

Keep away from light and store in a sealed container below 25℃.

API

Shenzhen Zhonglian Pharmaceutical Co., Ltd.

• Founded in:

  1988-10-11

• Address:

  Room 401, Building 1, Block B, No. 9 Danqing Road, Jinsha Community, Kengzi Street, Pingshan District, Shenzhen (One license, multiple locations enterprise)

• Tax NO.:

  91440300192188676Y

• Registered Funds:

  120 million yuan

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• Email:

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