Levofloxacin hydrochloride ear drops

Pharmacological action Levofloxacin is the levorotatory form of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism of action is to inhibit the activity of bacterial topoisomerase IV and DNA gyrase (both are type II topoisomerases), hindering the replication of bacterial DNA to achieve antibacterial effect. Levofloxacin has the characteristics of broad antibacterial spectrum and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter, and Gram-negative bacteria such as Pseudomonas aeruginosa, Haemophilus influenzae, and Neisseria gonorrhoeae. It also has good antibacterial effect on some methicillin-sensitive Staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, hemolytic Streptococci, and Legionella, Mycoplasma, and Chlamydia, but has poor effect on anaerobic bacteria and enterococci. Toxicological studies Genetic toxicity: The results of the Ames test, CHO/HGPRT mutation test, mouse micronucleus test, rat unscheduled DNA synthesis test (UDS), and mouse sister chromosome exchange test were all negative. The results of the in vitro CHL cell line chromosome aberration test and CHL/IU cell line sister chromosome exchange test were all positive. Carcinogenicity: Rats were given levofloxacin up to 100 mg/kg/day by dietary administration for 2 consecutive years, and no carcinogenicity was observed.

Levofloxacin Hydrochloride

This product is a light yellow-green clear liquid.

Used to treat otitis externa and otitis media caused by sensitive bacteria.

Ear drops. Adults should use 6-10 drops at a time, 2-3 times a day. After ear drops, bathe the ears for about 10 minutes. Increase or decrease the number of ear drops according to symptoms.

Occasionally there is middle ear pain and itching.

Patients who are allergic to this product and fluoroquinolones are contraindicated.

Precautions for children: Generally not for infants and young children. Precautions for pregnancy and lactation: Pregnant women should not use it. It can be used with caution only when there is an indication for use and the benefits outweigh the disadvantages. Breastfeeding women should stop breastfeeding when using it. Precautions for the elderly: Not yet clear.

Long-term and excessive use, after local absorption, may produce the same drug interactions as systemic medications, such as increasing the blood concentrations of drugs such as cyclosporine and probenecid, and interfering with the metabolism of caffeine.

seal.

0.5%

24 months

Shen ZHEN WAN HE Pharmaceutical Co., Ltd.

• Founded in:

  1992-07-28

• Address:

  Vanward Technology Building, No. 7 Huitong Road, Fenghuang Street, Guangming New District, Shenzhen

• Tax NO.:

  91440300618806532U

• Registered Funds:

  113.9981 million yuan

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