Daunorubicin Hydrochloride for Injection

Daunorubicin is a periodic nonspecific anti-tumor drug. Animal experiments have shown that it has a life-extending effect on mouse L1210 leukemia, and also shows a certain effect on cell lines resistant to methotrexate, 6-mercaptopurine and 5-fluorouracil. In addition, it has a life-extending effect on Yoshida sarcoma rats, and also shows a certain effect on cell lines resistant to cyclophosphamide, triethylenethiophosphoramide, 6-mercaptopurine, 5-chlorouracil, mitomycin C and chromomycin A3. The mechanism of action of daunorubicin lies in the nucleic acid synthesis process of cells. It can directly bind to DNA, hinder DNA synthesis and DNA-dependent RNA synthesis reactions.

The main ingredient of this product is daunorubicin hydrochloride.

This medicine is an orange-red loose powder that is easily soluble in glucose saline.

It is suitable for the treatment of acute leukemia, including myeloid leukemia that transforms from chronic to acute.

This product is for intravenous injection or drip. Before use, add 10ml of saline solution for injection to each vial to dissolve it. The dosage for one course of treatment for adults is 0.4-1.0mg/kg (body weight), and for children is 1.0mg/kg, once a day, for a total of 3-5 times, continuous or every other day. Repeat after one week of discontinuation. The total dosage should not exceed 600mg/square.

1. Myocardial damage, abnormal electrocardiogram, tachycardia, etc. Total dosage exceeding 25 mg/kg may cause severe myocardial damage. 2. Inhibition of bone marrow hematopoietic function; anemia, granulocytopenia, bleeding. 3. Allergies; fever, rash. 4. Liver damage; increased GOP, GPT, AI-P, jaundice. 5. Kidney damage; increased BUN, proteinuria. 6. Digestive organs; ulcerative stomatitis, loss of appetite, nausea, vomiting, etc. 7. Hair loss. 8. Mental symptoms such as fatigue, headache, dizziness, etc. 9. Chills, dyspnea, etc.

1. Patients with heart disease or a history of heart disease. 2. Patients with a history of severe allergy to this drug. 3. Pregnant and lactating women.

Precautions for children: 1. When using the drug in children, special attention should be paid to the occurrence of adverse reactions and use with caution. 2. If the drug must be administered to children and patients of childbearing age, the effect on the gonads should be considered. Precautions for pregnancy and lactation: 1. There are reports of teratogenicity in animal experiments (mice). Pregnant women or women who may become pregnant are prohibited from using the drug. 2. Avoid giving the drug to lactating women. If the drug must be used, breastfeeding should be stopped (the safety of using the drug during breastfeeding has not yet been determined).

It can be used in combination with prednisone, cytarabine or vinblastine to increase its efficacy.

Store in a sealed, dark, cool place. Valid for three years.

20mg (calculated as C27H29NO10)

24 months

Han Hui Pharmaceuticals Company Limited

• Founded in:

  2012-09-06

• Address:

  No. 2 Haizheng Road, Xukou Town, Fuyang District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100053653670B

• Registered Funds:

  1852.03035908 yuan

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