Ursodeoxycholic acid

Ursodeoxycholic acid accounts for a small part of human bile. After oral administration of ursodeoxycholic acid, the cholesterol saturation in bile is reduced by inhibiting the reabsorption of cholesterol in the intestine and reducing the secretion of cholesterol into bile. Cholesterol stones are gradually dissolved, probably due to the dispersion of cholesterol and the formation of liquid crystals. According to existing knowledge, the treatment of liver and cholestatic diseases with ursodeoxycholic acid capsules is mainly based on the relative replacement of lipophilic, detergent-like toxic bile acids by hydrophilic, cytoprotective and non-cytotoxic ursodeoxycholic acid, as well as the promotion of hepatocyte secretion and immunomodulation.

The main ingredient of this product is ursodeoxycholic acid. Its chemical name is 3a,7b-dihydroxy-5b-cholestane-24-acid.

This product is used for cholesterol gallstone formation and bile-deficient steatorrhea. It can also be used to prevent drug-induced stone formation and treat steatorrhea (after ileal resection).

1. Steroid gallstones and cholestatic liver disease. Take it with a small amount of water on time. Take 10 mg/kg of body weight at a time for lithotripsy treatment: generally takes 6 to 24 months. If the stones do not get smaller after 12 months of taking it, stop taking it. The treatment results are judged by ultrasound or X-ray examination every 6 months. 2. Bile reflux gastritis. Swallow it with water before going to bed at night. It must be taken regularly, one pill (250 mg) at a time, once a day. Generally take it for 10 to 14 days, and follow the doctor's advice to decide whether to continue taking the medicine.

The toxicity and side effects of this product are less than those of chenodeoxycholic acid. It generally does not cause diarrhea. Other occasional adverse reactions include constipation, allergies, headaches, dizziness, pancreatitis, and tachycardia. During the treatment period, it may cause calcification of gallstones and soft stools.

Acute biliary infection, biliary obstruction, pregnant and lactating women.

Precautions during pregnancy and lactation: Pregnant and lactating women are prohibited from using.

Ursodeoxycholic acid capsules should not be taken at the same time as drugs such as cholestyramine (cholestyramine), colestipol (colestipol), aluminum hydroxide and/or aluminum hydroxide-magnesium trisilicate, because these drugs can bind to ursodeoxycholic acid in the intestine, thereby hindering absorption and affecting efficacy. If the above drugs must be taken, ursodeoxycholic acid capsules should be taken two hours before or two hours after taking the drug. Ursodeoxycholic acid capsules can increase the absorption of cyclosporine in the intestine. Patients taking cyclosporine should monitor the serum concentration of cyclosporine and adjust the dose of cyclosporine if necessary. In some cases, taking ursodeoxycholic acid capsules can reduce the absorption of ciprofloxacin.

Keep away from light and sealed

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Sichuan Xieli Pharmaceutical Co., Ltd.

• Founded in:

  1992-04-17

• Address:

  No. 588, Middle Section of Mudan Avenue, Tianpeng Town, Pengzhou City, Sichuan Province

• Tax NO.:

  91510000621814779U

• Registered Funds:

  15 million yuan

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