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Succimer Capsules

Function and Efficacy

Pharmacology: This product is an effective oral heavy metal detoxifier. The mechanism of action is that the two active sulfhydryl groups in the molecule can capture the metals that have been bound to the enzyme system in the tissue, forming a stable water-soluble chelate that is excreted in the urine, restoring the activity of the enzyme containing sulfhydryl groups and relieving the symptoms of poisoning caused by heavy metals. This product can specifically bind to lead, reduce the absorption and retention of lead from the gastrointestinal tract. It reduces the blood lead concentration, but after a short period of medication, it is easy to free lead from the bones and redistribute it, causing a rebound increase in blood lead, so multiple courses of medication should be used depending on the situation. This product can also form chelates with mercury, arsenic, etc. Toxicology: The LD50 of mice and rats is 3000mg/kg. Chronic toxicity studies on dogs have found that oral administration of 300mg/kg of this product per day can cause the death of some dogs.

Ingredients

The main ingredient of this product and its chemical name are: 2,3-dimercaptosuccinic acid.

Indication

It is used to treat metal poisoning such as lead, mercury, arsenic, nickel, and copper. It has a good effect on lead poisoning. It can be used to treat Wilson's disease.

Usage and Dosage

Oral administration: 0.5g once, 3 times a day, for 3 consecutive days as a course of treatment, stop for 4 days before using again; or 0.5g each time, 2 times a day, take the medicine every other day, for a total of 10 days, stop for 5 days before using again. Generally, 2-3 courses of treatment are sufficient. Children can take 10mg/kg or 350mg/m2 orally each time, once every 8 hours, for 5 consecutive days, then change to once every 12 hours, for 2 consecutive weeks, for a total of 19 days as a course of treatment.

Adverse Reactions

Common adverse reactions in adults and children include gastrointestinal reactions such as nausea, vomiting, diarrhea, loss of appetite, loose stools, etc. Rashes are occasionally seen (about 4% of adults), and serum aminotransferases are transiently elevated (6% to 10%). Neutropenia is occasionally seen. [Contraindications] Severe liver dysfunction and pregnant women are contraindicated.

Precautions

It is contraindicated in patients with severe liver dysfunction and pregnant women.

Drug Interactions

Not sure yet.

Storage

Keep away from light, tightly closed, in a cool place.

Packaging Specification

0.1g

Validity Period

36 months

Manufacturer

Shandong Dyne Marine Organism Pharmaceutical Co., Ltd.

  • Founded in:

    1994-10-27
  • Address:

    No. 18, Fuyuan South Road, Rongcheng City, Shandong Province
  • Tax NO.:

    913700006137729862
  • Registered Funds:

    62 million yuan
  • Website:

  • Email:

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