Simvastatin Capsules

This product itself is inactive. The hydrolysis product after oral absorption competitively inhibits the rate-limiting enzyme hydroxymethylglutaryl coenzyme A reductase in the cholesterol synthesis process in the body, reducing the synthesis of cholesterol and increasing the synthesis of low-density lipoprotein receptors. The main site of action is in the liver, resulting in lower blood cholesterol and low-density lipoprotein cholesterol levels, moderately lower serum triglyceride levels and increased blood high-density lipoprotein levels. This has an effect on the prevention and treatment of atherosclerosis and coronary heart disease. In mice, 3-4 times the human dose can cause cancer, but no increase in tumor occurrence has been observed in large-scale long-term clinical trials in humans. Existing studies have not found that this product has a mutagenic effect.

The main ingredient of this product is simvastatin.

This product is a capsule with white or off-white contents.

Used for the treatment of hypercholesterolemia and combined hyperlipidemia; prevention and treatment of coronary heart disease and cerebral stroke.

The usual oral dose for adults is 10-20 mg, once a day, taken at dinner. The dose can be adjusted as needed, but the maximum dose should not exceed 80 mg per day.

1. The most common adverse reaction of this product is gastrointestinal discomfort, and others include headache, rash, dizziness, blurred vision and taste disturbance. 2. It may occasionally cause a reversible increase in blood aminotransferase. Therefore, liver function needs to be monitored. 3. Rare adverse reactions include impotence and insomnia. 4. Rare adverse reactions include myositis, myalgia, and rhabdomyolysis, which are manifested as muscle pain, fatigue, fever, and are accompanied by increased blood creatine phosphokinase, myoglobinuria, etc. Rhabdomyolysis can lead to renal failure, but it is rare. The combination of this product with immunosuppressants, folic acid derivatives, niacin, gemfibrozil, erythromycin, etc. can increase the risk of myopathy. 5. There have been reports of hepatitis, pancreatitis and allergic reactions such as angioedema.

1. Patients who are allergic to simvastatin should not use this drug. Patients who are allergic to other HMG-CoA reductase inhibitors should use this drug with caution. 2. Patients with active liver disease or unexplained persistent elevation of blood aminotransferase should not use this drug.

Precautions for children: Limited use in children, long-term safety has not been established. Precautions for pregnancy and lactation: Because this product can cause fetal maldevelopment in animal experiments and it is unclear whether it is excreted in breast milk, it is not recommended for use in pregnant women and nursing mothers. Precautions for the elderly: Elderly patients need to adjust the dose according to liver and kidney function.

1. The combination of this product with oral anticoagulants can prolong the prothrombin time and increase the risk of bleeding. 2. The combination of this product with immunosuppressants such as cyclosporine, erythromycin, gemfibrozil, niacin, etc. can increase the risk of myolysis and acute renal failure. 3. Colestipol and cholestyramine can reduce the bioavailability of this product, so this product should be taken 4 hours after taking the former.

Keep in a light-proof and airtight container.

5mg

24 months

Hubei Shubang Pharmaceutical Co., Ltd.

• Founded in:

  2012-04-17

• Address:

  No. 1 Sibao Road, Xiantao City

• Tax NO.:

  914290045942134679

• Registered Funds:

  48 million yuan

• Email:

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