Aripiprazole tablets

Aripiprazole has high affinity for D2, D3, 5-HT1A, and 5-HT2A receptors, and moderate affinity for D4, 5-HT2C, 5-HT7, alpha;1, H1 receptors, and 5-HT reabsorption sites. Aripiprazole is a partial agonist of D2 and 5-HT1A receptors, and an antagonist of 5-HT2A receptors. Like other drugs with anti-schizophrenia effects, the mechanism of action of aripiprazole is still unclear. However, it is believed to be mediated by partial agonism of D2 and 5-HT1A receptors and antagonism of 5-HT2A receptors. The action with other receptors may produce some other clinical effects of aripiprazole, such as the antagonism of alpha;1 receptors, which can explain its phenomenon of postural hypotension.

Chemical name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)quinolinone.

This product is a film-coated tablet; yellow tablet.

1. For the treatment of schizophrenia. 2. The efficacy of aripiprazole in the treatment of schizophrenia has been established in short-term (4-week and 6-week) controlled trials in patients with schizophrenia. Physicians who choose aripiprazole for long-term treatment should regularly re-evaluate the long-term efficacy of the drug for individual patients.

For patients who switch from other antipsychotics to this product: some patients can stop the antipsychotics they were taking immediately; while other patients should gradually stop the antipsychotics they were taking when starting to use this product. The duration of taking antipsychotics at the same time should be minimized. Adults: once a day. The initial dose is 10 mg. After 2 weeks of medication, the dose can be gradually increased according to the individual's efficacy and tolerance, up to a maximum of 30 mg. After that, this dose can be maintained unchanged. The maximum daily dose should not exceed 30 mg

Not yet clear

Patients with known allergies to this product are contraindicated

Precautions for children: There is currently a lack of sufficient clinical experience in children. Precautions for pregnancy and lactation: It is not clear whether this product is safe for pregnant women to take. For pregnant women, the pros and cons should be weighed to decide whether to take this product. It can only be used when the potential benefits outweigh the risks, otherwise it should not be taken during pregnancy and lactation. Precautions for the elderly: Aripiprazole is well tolerated by the elderly at the recommended dose and no dose adjustment is required.

1. Use with caution when combined with other drugs that act on the central nervous system and alcohol. 2. Aripiprazole may enhance the effects of certain antihypertensive drugs. 3. CYP3A4 inducers (such as carbamazepine) will increase the clearance rate of aripiprazole and reduce its blood concentration. CYP3A4 inhibitors (such as ketoconazole) or CYP2D inhibitors (such as quinidine, fluoxetine, paroxetine) can inhibit the elimination of aripiprazole and increase its blood concentration.

Sealed, stored in a cool and dry place

15mg

24 months

ZheJiang Otsuka Pharmaceutical Co., Ltd.

• Founded in:

  1991-10-12

• Address:

  No. 1 Shangguafan, Jinnan Street, Lin'an District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100609129453D

• Registered Funds:

  $54,333,333

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