Hydrocortisone Acetate Tablets

This product is a drug of adrenal cortex hormone. It has multiple pharmacological effects such as anti-inflammatory, anti-allergic and immunosuppressive. 1 Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the manifestation of inflammation. 2 Immunosuppressive effect: prevent or inhibit cell-mediated immune response, delayed allergic reaction, and reduce the expansion of primary immune response. 3 Anti-toxic and anti-shock effect: Glucocorticoids can counteract the stimulation of bacterial endotoxins on the body, reduce cell damage, and play a role in protecting the body.

The main ingredients of this product and its chemical name: The main ingredient of this product is hydrocortisone acetate. Its chemical name is: 11beta;,17alpha;,21-trihydroxypregnane-4-ene-3,20-dione-21-acetate. Its structural formula is: Molecular formula: C24H32O6 Molecular weight: 404.50.

This product is white tablets.

It is mainly used for replacement therapy of adrenal insufficiency and congenital adrenal hyperplasia.

Oral administration: 20-30 mg per day, 2/3 in the morning and 1/3 after lunch. In case of stress, the dosage should be increased appropriately, up to 80 mg per day, taken in divided doses. The therapeutic dose for children is 20-25 mg/M2 per day, taken in 3 divided doses.

There are generally no obvious adverse reactions when glucocorticoids are used in physiological dose replacement therapy. Adverse reactions often occur when the pharmacological dose of the drug is used, and are closely related to the course of treatment, dosage, type of medication, usage and route of administration. Common adverse reactions of steroid hormone drugs are as follows: 1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome facial and body shape, weight gain, lower limb edema, purple lines, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, pathological fractures of long bones), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial pressure

Patients who are allergic to this product and other steroid hormones are prohibited from using it. Patients with the following diseases should not use it in general. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, trauma repair period, corneal ulcer, hyperadrenocortical syndrome, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibacterial drugs such as chickenpox, measles, fungal infections, severe osteoporosis, etc.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time. Exceptions are adrenocortical hypofunction and congenital adrenal hyperplasia. Precautions for pregnancy and lactation: 1. Medication during pregnancy: Glucocorticoids can pass through the placenta. Animal experimental studies have confirmed that administration during pregnancy can increase the incidence of cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. The use of pharmacological doses of glucocorticoids in humans can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. 2. Medication during lactation: Since glucocorticoids can be excreted in breast milk, they have adverse effects on infants, such as growth inhibition and adrenal cortical function inhibition. Pregnant and lactating women should avoid using them as much as possible after weighing the pros and cons. Precautions for the elderly: Elderly patients are prone to hypertension and diabetes when using glucocorticoids. Elderly patients, especially postmenopausal women, are prone to aggravating osteoporosis when using glucocorticoids.

1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by it. 7. When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. 10. When used in combination with cardiac glycosides, it can increase the occurrence of digitalis toxicity and arrhythmia. 11 When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12 When used in combination with ephedrine, it can enhance its metabolic clearance. 13 When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14 It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15 It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16 When used in combination with salicylates, it can reduce the concentration of plasma salicylate. ⒄ When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

Keep away from light and store in a sealed container.

20mg

36 months

Tianjin Jinjin Pharmaceutical Co., Ltd.

• Founded in:

  1998-10-13

• Address:

  Zhangjiawo Industrial Zone, Xiqing Economic Development Zone (multiple address information exists)

• Tax NO.:

  91120111103851027X

• Registered Funds:

  24.4898 million yuan

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