Nabumetone dry suspension

This product is a non-acidic non-steroidal anti-inflammatory drug and a prodrug. It is rapidly metabolized to 6-methoxy-2-naphthylacetic acid (6-MNA) in the liver and has antipyretic, analgesic and anti-inflammatory effects. The anti-inflammatory, analgesic and antipyretic effects of this product are related to the fact that the active metabolites of nabumetone inhibit the synthesis of prostaglandins in inflammatory tissues. This product has little effect on the gastric mucosa: this product is a non-acidic, non-ionic prodrug, and has no obvious local direct effect on the gastric mucosa during the absorption process; at the same time, this product has little inhibitory effect on the physiological cyclooxygenase of the gastric mucosa. Therefore, the incidence of gastrointestinal mucosal erosion and bleeding caused by this product is low. This product has no effect on bleeding and coagulation: this product has no effect on the platelet aggregation induced in vitro in blood samples of healthy volunteers.

The main ingredient of this product is nabumetone.

This product is white or off-white powder.

1. Various acute and chronic inflammatory arthritis; 2. Soft tissue rheumatism; 3. Sports soft tissue injuries, sprains and contusions, etc.; 4. Others such as surgical pain, post-traumatic pain, toothache, pain after tooth extraction, dysmenorrhea, etc.

Dissolve with warm water, shake well and take, 1 bag (1.0g of nabumetone) at a time, before going to bed every night, the maximum daily dose is 2 bags (2.0g of nabumetone) taken in two doses, or follow the doctor's advice.

(1) Gastrointestinal tract: Nausea, vomiting, indigestion, diarrhea, abdominal pain and constipation are about 1% to 3%. Upper gastrointestinal bleeding is about 0.7%. In the cases using this product, the incidence of ulcers in the short-term treatment (6 weeks to 6 months) group and the long-term treatment (8 years) group were 0.1% and 0.95%, respectively. The incidence of diarrhea increases with daily use of 2g of nabumetone. (2) Nervous system: Manifestations include headache, dizziness, tinnitus, sweating, insomnia, drowsiness, tension and dreaminess, with an incidence of less than 1.5%. (3) Skin: Rash and itching are about 2.1%, and edema is about 1.1%.

It is contraindicated for patients with active gastrointestinal ulcers or bleeding, severe liver function abnormalities, or allergies to this product and other non-steroidal anti-inflammatory drugs.

Precautions for children: Forbidden. Precautions for pregnancy and lactation: Pregnant women are not recommended to use this product in the last 3 months of pregnancy and during lactation. Precautions for the elderly: Elderly patients should generally not take more than 1 gram (2 bags) per day, usually 0.5 grams (1 bag) per day will achieve satisfactory results.

(1) The combined use of aluminum hydroxide gel, aspirin or acetaminophen does not affect the absorption rate of this product. However, it is generally not recommended to use two or more non-steroidal anti-inflammatory drugs at the same time. (2) There is no interaction between this product and warfarin in healthy volunteers. However, there is no data on the combined use of these two drugs in patients. (3) When this product is used in combination with acetyl anticonvulsants and sulfonylurea hypoglycemic drugs, the dosage should be appropriately reduced.

seal.

1.0g

24 months

NanChang Helioeast Pharmaceutical Co., Ltd.

• Founded in:

  2002-11-26

• Address:

  No. 789, Torch Street, High-tech Zone, High-tech Industrial Development Zone, Nanchang City, Jiangxi Province

• Tax NO.:

  91360106744293141A

• Registered Funds:

  30 million yuan

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