Ramosetron Hydrochloride for Injection

Pharmacological action 1. 5-HT3 receptor antagonism In the 5-hydroxytryptamine-induced guinea pig isolated colon contraction test and rat and ferret heart rate slowing reflex (Bezold-Jarisch reflex) test, this drug showed antagonism to 5-HT3 receptors. 2. Inhibition of vomiting induced by anti-malignant tumor drugs This drug showed an inhibitory effect on vomiting induced by cisplatin in ferrets when given before vomiting or after the initial vomiting. Anti-malignant tumor drugs such as cisplatin can free 5-hydroxytryptamine from chromaffin cells in the digestive tract. 5-hydroxytryptamine binds to the 5-HT3 receptors present in the gastrointestinal mucosa at the ends of the vagus nerve.

The main ingredient of this product is ramosetron hydrochloride, and its chemical name is: (-)-5-(R)-(1-methyl-indole-3-carbonyl)-4,5,6,7-tetrahydro-benzimidazole hydrochloride.

This product is white or off-white loose mass or powder.

Prevent and treat gastrointestinal symptoms such as nausea and vomiting caused by anti-malignant tumor drugs.

Before use, dilute with 2 ml of 5% or 10% glucose solution, saline or water for injection. Usually, adults are given 0.3 mg intravenously once a day. In addition, the dosage can be appropriately increased or decreased according to age and symptoms. If the effect is not obvious, the same dose can be given additionally, but the daily dosage should not exceed 0.6 mg.

Of the 352 cases of ramosetron hydrochloride that underwent safety evaluation prior to marketing, 7 cases (2.0%) experienced adverse reactions. The main adverse reactions are fever, headache, and heaviness of the head. Severe adverse reactions: People who are allergic to this product may experience allergic-like symptoms such as chest tightness, dyspnea, wheezing, facial flushing, redness, itching, cyanosis, low blood pressure, and even shock. The incidence is not yet clear. In addition, there have been reports of epileptic seizures with the use of other 5-HT3 receptor antagonist antiemetics abroad. Other adverse reactions: less than 0.1% to 1% headache, heaviness of the head, diarrhea, body fever, fever in the head, and numbness of the tongue. The incidence is unclear redness, rash, itching, constipation, increased BUN,

Patients with a history of allergy to the ingredients of this drug are contraindicated.

This drug may react with mannitol injection, bumetanide injection, furosemide injection, etc., so do not use them together. However, it can be used by adding 200 ml of normal saline to furosemide injection containing 20 mg of furanilic acid and mixing with one ampoule of this drug.

Keep away from light and at room temperature. Valid for 24 months.

0.3mg

Wuxi Taxus Pharmaceutical Co., Ltd.

• Founded in:

  2004-05-31

• Address:

  No. 111, Qinxin Road, Donggang Town, Xishan District, Wuxi City

• Tax NO.:

  9132020576243151XT

• Registered Funds:

  190.31 million yuan

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