Acyclovir Gel

This product is an antiviral drug. It has inhibitory effects on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. After entering the cells infected with herpes virus, this product competes with deoxynucleoside for viral thymidine kinase or cellular kinase, and the drug is phosphorylated into activated acyclovir triphosphate, which then inhibits viral replication in two ways: ① Interfering with viral DNA polymerase and inhibiting viral replication; ② Under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. This product has a special affinity for viruses, but has low toxicity to mammalian host cells. There are reports of carcinogenicity in in vitro cell transformation assays, but no evidence of carcinogenicity has been found in animal experiments. Some animal experiments show that high concentrations of drugs can cause mutations, but there is no evidence of chromosomal changes. Carcinogenicity of this product

The main ingredient of this product is acyclovir, and its chemical name is: 9-[(2-hydroxyethoxy)methyl]guanine

This product is white gel.

This product is suitable for: 1. Herpes simplex virus infection: used for the initial and recurrent cases of genital herpes virus infection, and for the prevention of recurrent cases. 2. Herpes zoster: used for the treatment of herpes zoster in people with normal immune function and mild cases in people with immunodeficiency. 3. Treatment of chickenpox in people with immunodeficiency.

Oral 1. Genital herpes for the first time and mucous membrane herpes simplex in immunocompromised patients: The usual dose for adults is 0.2g once, 5 times a day, for 10 days; or 0.4g once, 3 times a day, for 5 days; for recurrent infection, 0.2g once, 5 times a day, for 5 days; for chronic suppressive therapy of recurrent infection, 0.2g once, 3 times a day, for 6 months, and if necessary, the dose can be increased to 5 times a day, 0.2g once, for 6 to 12 months. 2. Herpes zoster: The usual dose for adults is 0.8g once, 5 times a day, for 7 to 10 days. 3. Adult patients with renal insufficiency should adjust the dose according to the table below; 4. Varicella: Children over 2 years old should take 20m once according to body weight.

Occasionally, dizziness, headache, joint pain, nausea, vomiting, diarrhea, stomach discomfort, loss of appetite, thirst, leukocytopenia, slight increase in proteinuria and urea nitrogen, skin itching, etc. may occur. Acne, insomnia, and menstrual disorders may occur occasionally with long-term administration.

It is contraindicated in patients who are allergic to acyclovir.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

1. Combination with zidovudine can cause nephrotoxicity, manifested as deep lethargy and fatigue. 2. Competitive inhibition of organic acid secretion with probenecid. Combination with probenecid can slow down the excretion of this product, prolong the half-life, and accumulate the drug in the body.

Sealed and stored in a cool place.

3%

24 months

China Resources Sanjiu (NanChang) Pharmaceutical Co., Ltd.

• Founded in:

  2000-10-20

• Address:

  No. 398 Dongsheng Avenue, Changdong Industrial Zone, Qingshan Lake District, Nanchang City, Jiangxi Province

• Tax NO.:

  913601007239228188

• Registered Funds:

  70.39 million yuan

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