Nabumetone dispersible tablets

This product is a non-acidic non-steroidal anti-inflammatory drug, which is rapidly metabolized to 6-methoxy-2-naphthylacetic acid (6-MNA) in the liver and exerts antipyretic, analgesic and anti-inflammatory effects. 1 The anti-inflammatory, analgesic and antipyretic effects are related to the fact that the active metabolites of cabutimetone inhibit the synthesis of prostaglandins in inflammatory tissues. 2 Little effect on gastric mucosa: This product is a non-acidic, non-ionic prodrug, which has no obvious local direct effect on the gastric mucosa during the absorption process; at the same time, this product has little inhibitory effect on the physiological cyclooxygenase of the gastric mucosa. Therefore, the incidence of gastrointestinal mucosal erosion and bleeding caused by this product is low. 3 No effect on bleeding and coagulation: This product induces platelet count in vitro in blood samples of healthy volunteers.

The main ingredients and chemical names of this product are: The main ingredient is nabumetone, whose chemical name is 4-(6-methoxy-2-naphthyl)-2-butanone.

This product is white tablets.

Rheumatoid arthritis, osteoarthritis.

1Usual dosage for adults is 1.0g (2 tablets) orally, once a day. The maximum daily dosage is 2g, divided into two doses. Adults weighing less than 50kg can start with 0.5g (1 tablet) daily. Gradually increase to the effective dose. 2The dosage for children has not yet been established.

1 Gastrointestinal tract: nausea, vomiting, indigestion, diarrhea, abdominal pain and constipation, about 1% to 3%. Upper gastrointestinal bleeding, about 0.7%. In the cases using this product, the incidence of ulcers was 0.1% in the short-term treatment group (6 weeks to 6 months) and 0.95% in the long-term treatment group (8 years). The incidence of diarrhea increased with daily oral administration of 2g of nabumetone. 2 Nervous system: Manifestations include headache, dizziness, tinnitus, sweating, insomnia, drowsiness, tension and dreaming, with an incidence of less than 1.5%. 3 Skin: rash and itching, about 2.1%, edema, about 1.1%. 4 Rare or occasional adverse reactions include jaundice, abnormal liver function, anxiety, depression, paresthesia, tremor, dizziness,

It is contraindicated for patients with active peptic ulcer or bleeding, severe liver function abnormalities, and allergies to this product and other non-steroidal anti-inflammatory drugs.

Precautions for children: Not recommended for children. Precautions for pregnancy and lactation: Not recommended for pregnant and lactating women. Precautions for the elderly: Many elderly patients usually have higher blood drug concentrations when taking drugs. The recommended daily dose for this age group does not exceed 1 gram (2 tablets), and some patients can get satisfactory results by taking 0.5 grams (1 tablet).

1. The absorption rate of this product is not affected by the combined use of aluminum hydroxide gel, aspirin or acetaminophen. However, it is generally not recommended to use two or more non-steroidal anti-inflammatory drugs at the same time. 2. There is no interaction between this product and the anticoagulant warfarin in healthy volunteers. However, there is no data on the combined use of these two drugs in patients. 3. When this product is used in combination with acetyl anticonvulsants and sulfonylurea hypoglycemic drugs, the dosage should be appropriately reduced.

Keep away from light and store in a sealed container.

0.5g

Tentative 12 months

Beijing Jinchengtaier Pharmaceutical Co., Ltd.

• Founded in:

  2003-07-15

• Address:

  No. 9 Mintai Road, Beiwu Town, Shunyi District, Beijing (Science and Technology Innovation Functional Area)

• Tax NO.:

  911101057526411930

• Registered Funds:

  150 million yuan

• Website:

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