Granisetron Hydrochloride Capsules

This product is a potent, highly selective 5-HT3 receptor antagonist in peripheral neurons and the central nervous system. It has a good preventive and therapeutic effect on nausea and vomiting caused by chemotherapy, radiotherapy and surgery. Factors such as chemotherapy, radiotherapy and surgery can cause enterochromaffin cells to release 5-HT, which can activate the 5-HT3 receptors of the central nervous system or vagus nerve, triggering the vomiting reflex. This product can selectively block the triggering of this reflex. Due to the high selectivity of this product, it does not have the side effects of other antiemetics, such as extrapyramidal reactions and excessive sedation.

The main ingredient of this product is granisetron hydrochloride.

This product is in the form of capsules.

Used for nausea and vomiting caused by radiotherapy and cytotoxic chemotherapy.

This product is taken orally and used in combination with intravenous and intramuscular injections. 1 Adults: The dose is generally 1 mg each time, twice a day; 2 Children: The dose is 20 μg/kg each time, twice a day. Generally, take it 1 hour before chemotherapy and the second time 12 hours later.

Common side effects include headache, fatigue, fever, constipation and gastrointestinal dysfunction, and occasionally transient asymptomatic increase in liver transaminase. The above reactions are mild and do not require special treatment.

1. Patients who are allergic to this product or related compounds are prohibited from using this product. 2. Patients with gastrointestinal obstruction are prohibited from using this product.

Precautions for children: Not recommended for children. Precautions for pregnancy and lactation: Multiple in vitro and in vivo evaluation tests have confirmed that this drug has no genetic toxicity to mammalian cells. Animal experiments have confirmed that it is not teratogenic, but there is no such experience in humans. In addition, there is no information on the secretion and excretion of this product in breast milk. Therefore, the following rules should be followed: ① Pregnant women should not use it unless necessary; ② Lactating women should use it with caution, and if using this product, they should stop breastfeeding. Precautions for the elderly: No dosage adjustment is required for the elderly.

When used simultaneously with rifampicin or other liver enzyme inducing drugs, the blood concentration of this product will be reduced and the dosage should be appropriately increased.

Store below 30℃, do not freeze, keep in a dark and airtight place. 『Expiration』2 years.

1 mg (as granisetron)

24 months

Shandong Zibo Xinda Pharmaceutical Co., Ltd.

• Founded in:

  1993-03-11

• Address:

  No. 1, Lutai Avenue, Zibo High-tech Zone

• Tax NO.:

  9137030361328152XT

• Registered Funds:

  84.93 million yuan

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