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Amoxicillin Granules

Function and Efficacy

Amoxicillin is a penicillin antibiotic that has good antibacterial activity against Streptococcus such as Streptococcus pneumoniae and hemolytic Streptococcus, aerobic Gram-positive cocci such as non-penicillinase-producing Staphylococci and Enterococcus faecalis, aerobic Gram-negative bacteria such as Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae, and Helicobacter pylori. Amoxicillin exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls, which can quickly dissolve and rupture bacteria into spherical bodies.

Ingredients

The main ingredient of this product is amoxicillin, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-[(R)-(-)-2-amino-2-(4-hydroxyphenyl)acetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate.

Name Description Content CAS NO. Manufacturer
AmoxicillinIngredients

Amoxicillin is a penicillin antibiotic that has good antibacterial activity against Streptococcus such as Streptococcus pneumoniae and hemolytic Streptococcus, aerobic Gram-positive cocci such as non-penicillinase-producing Staphylococci and Enterococcus faecalis, aerobic Gram-negative bacteria such as Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae, and Helicobacter pylori. Amoxicillin exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls, which can quickly dissolve and rupture bacteria into spherical bodies.

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26787-78-0 30

Appearance

This product is a granule, the contents are white, off-white or light yellow granules and powder, with a fragrant smell and sweet taste.

Indication

1. Otitis media, sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections caused by hemolytic streptococci, pneumococcus, staphylococcus or Haemophilus influenzae. 2. Urogenital tract infections caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infections caused by hemolytic streptococci, staphylococcus or Escherichia coli. 4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococci, pneumococcus, staphylococcus or Haemophilus influenzae. 5. Acute simple gonorrhea. 6. This product can also be used to treat typhoid fever, typhoid carriers and leptospirosis; amoxicillin can also be used in combination with clarithromycin and lansoprazole to eradicate gastric and duodenal Helicobacter pylori and reduce the recurrence rate of peptic ulcers.

Usage and Dosage

Adults: 0.5g at a time, once every 6 to 8 hours, and the daily dose shall not exceed 4g. Oral administration. Tear open the small bag, pour the powder into an appropriate amount of cold boiled water, shake well, and then take it. Children: The daily dose is 20 to 40 mg/kg based on body weight, once every 8 hours. Newborns and premature infants take 50 mg orally each time, and infants under 3 months old take a daily dose of 30 mg/kg based on body weight. Reference dosage of amoxicillin granules for children: Age 125 mg/bag/time 250 mg/bag/time Daily dosage Infants under 3 months old 0.4 bag 0.2 bag 3 times a day or as prescribed by a doctor Under one year old 0.5 bag 0.25 bag 3 times a day or as prescribed by a doctor 1 to 3 years old 1 bag 1/2 bag 3 times a day or as prescribed by a doctor 3 to 5 years old 1.5 bags 3/4 bags 3 times a day or as prescribed by a doctor 5 to 10 years old 2 bags 1 bag 3 times a day or as prescribed by a doctor 10 years old and above 2 to 3 bags 1 to 1.5 bags 3 times a day or as prescribed by a doctor

Adverse Reactions

1 Gastrointestinal reactions such as nausea, vomiting, diarrhea and pseudomembranous colitis. 2 Allergic reactions such as rash, drug fever and asthma. 3 Anemia, thrombocytopenia, eosinophilia, etc. 4 Serum aminotransferase may be slightly elevated. 5 Superinfection caused by Candida or drug-resistant bacteria. 6 Occasionally, central nervous system symptoms such as excitement, anxiety, insomnia, dizziness and abnormal behavior may occur.

Precautions

1. Patients allergic to penicillin are contraindicated. 2. A penicillin sodium skin test must be performed before use, and patients with a positive reaction are contraindicated.

Special Population Medication

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Animal reproduction studies have shown that amoxicillin at 10 times the human dose did not damage the fertility and fetuses of rats and mice. However, there is a lack of adequate controlled studies in humans. Given that animal reproduction studies cannot fully predict human reactions, pregnant women should only use this product when it is necessary. Since a small amount of amoxicillin can be secreted in breast milk, nursing mothers may cause allergies in their babies after taking it. Precautions for the elderly: Not yet clear.

Drug Interactions

1. Probenecid competitively reduces the renal tubular secretion of this product. The simultaneous use of the two can cause an increase in the blood concentration of amoxicillin and a prolonged half-life. 2. Chloramphenicol, macrolides, sulfonamides and tetracyclines interfere with the antibacterial effect of amoxicillin in vitro, but the clinical significance is unclear.

Storage

Keep away from light, seal tightly and store in a cool dark place.

Packaging Specification

0.125 g

Validity Period

24 months.

Manufacturer

Hunan Zhonghe Pharmaceutical Co., Ltd.

  • Founded in:

    1992-05-03
  • Address:

    No. 186, Tongzipo West Road, Changsha High-tech Development Zone
  • Tax NO.:

    914301006167706446
  • Registered Funds:

    30 million yuan
  • Website:

  • Email:

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