Aspirin extended-release tablets

This product is a non-steroidal anti-inflammatory drug. 1 Analgesic effect: It is mainly through inhibiting the synthesis of prostaglandins and other substances that can make pain sensitive to mechanical or chemical stimulation (such as bradykinin, histamine), and it is a peripheral analgesic. However, the possibility of central analgesia (possibly acting on the hypothalamus) cannot be ruled out; 2 Anti-inflammatory effect: The exact mechanism is still unclear. It may be because this product acts on inflamed tissues and inhibits the synthesis of prostaglandins or other substances that can cause inflammatory reactions (such as histamine) to play an anti-inflammatory role. Inhibition of the release of lysosomal enzymes and leukocyte chemotaxis may also be related to it; 3 Antipyretic effect: It may act on the hypothalamic temperature regulation center to cause peripheral vasodilation, increased skin blood flow, sweating, and increased heat dissipation to play an antipyretic role. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus; 4. Anti-rheumatic effect: The anti-rheumatic mechanism of this product, in addition to antipyretic and analgesic effects, is mainly anti-inflammatory; 5. Inhibitory effect on platelet aggregation: It works by inhibiting platelet cyclooxygenase and reducing the production of prostaglandins.

Acetylsalicylic acid.

1. Analgesic and antipyretic: It can relieve mild or moderate pain, such as headache, toothache, neuralgia, muscle pain and menstrual pain. It is also used to reduce fever for colds and flu. This product can only relieve symptoms, but cannot treat the causes of pain and fever, so other drugs must be used at the same time to treat the causes; 2. Anti-inflammatory and anti-rheumatic: It is a commonly used drug for the treatment of rheumatic fever. It can reduce fever, improve joint symptoms and reduce erythrocyte sedimentation rate, but it cannot eliminate the basic pathological changes of rheumatic fever, nor can it treat and prevent heart damage and other complications; 3. Arthritis: In addition to rheumatoid arthritis, this product is also used to treat rheumatoid arthritis and can improve symptoms, but the cause must be treated at the same time. In addition, this product is also used for osteoarthritis, ankylosing spondylitis, gouty arthritis, juvenile arthritis and other

Antipyretic and analgesic: 2-3 tablets (0.162g per tablet), twice a day. Anti-rheumatic: 4-5 tablets (0.162g per tablet), twice a day, or as directed by a doctor. Children should take a reduced dose.

The doses generally used for antipyretic and analgesic rarely cause adverse reactions. Long-term and large-scale use of the drug (for the treatment of rheumatic fever), especially when the blood concentration of the drug is 200?g/m1, is more likely to cause adverse reactions. The higher the blood concentration, the more obvious the adverse reactions: 1. Central nervous system: reversible tinnitus and hearing loss occur, which often occur after a certain course of treatment and the blood concentration reaches 200-300mg/ml; 2. Allergic reaction: occurs in 0.2% of patients, manifested as asthma, urticaria, angioneurotic edema or shock. Most of them are susceptible people, and they quickly develop breathing difficulties after taking the drug. In severe cases, they can cause death, which is called aspirin asthma. Some are aspirin allergy, asthma and nasal polyps triad, which is often related to genetic and environmental factors; 3. Liver and kidney function damage is related to the dosage, especially when the dosage is too large and the blood concentration reaches 250mg/ml. The damage is reversible and can be restored after stopping the drug, but there are reports of renal papillary necrosis.

1. It is contraindicated for patients with active ulcer disease or gastrointestinal bleeding caused by other reasons; 2. It is contraindicated for patients with hemophilia or thrombocytopenia; 3. It is contraindicated for patients with a history of allergy to aspirin or other non-steroidal anti-inflammatory drugs, especially those with asthma, angioedema or shock; 4. It should be used with caution in patients who are allergic to this product, children, the elderly, pregnant women and lactating women.

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Use with caution in the elderly.

1. The efficacy is not enhanced when used with other non-steroidal anti-inflammatory drugs, because this product can reduce the bioavailability of other non-steroidal anti-inflammatory drugs. Long-term and large-scale use of this product with acetaminophen may cause kidney diseases including renal papillary necrosis, renal cancer or bladder cancer; 2. When used with any drug that can cause hypoprothrombinemia, thrombocytopenia, reduced platelet aggregation function or gastrointestinal ulcer bleeding, there may be a risk of aggravating coagulation disorders and causing bleeding; 3. Used with anticoagulants (dicoumarol, heparin, etc.) and thrombolytic drugs (streptokinase, urokinase), it may increase the risk of bleeding; 4. Urine alkalinizing drugs (sodium bicarbonate, etc.) and antacids (long-term and large-scale use) can increase the excretion of this product in urine and reduce the blood drug concentration. However, when the blood drug solubility of this product has reached a stable state and the alkaline drug is discontinued, the blood drug concentration of this product can be increased to a toxic level. Carbonic anhydrase inhibitors can alkalinize urine, but can cause metabolic acidosis. It can not only reduce the blood drug concentration, but also increase the amount of this product that penetrates into the brain tissue, thereby increasing toxic reactions; 5 Uric acid drugs can reduce the excretion of this product and increase its blood drug concentration. Patients whose blood drug concentration has reached a stable state may increase the blood drug concentration of this product and increase toxic reactions after adding uricidification drugs; 6 Glucocorticoids (hormones for short) can increase the excretion of salicylates. In order to maintain the blood drug concentration of this product when used together, the dosage of this product should be increased if necessary. Long-term use of this product and hormones, especially when used in large quantities, increases the risk of gastrointestinal ulcers and bleeding. Therefore, it is not recommended to use these two drugs at the same time in clinical practice. 7 The hypoglycemic effect of insulin or oral hypoglycemic drugs can be enhanced and accelerated by using this product together. 8 When used together with methotrexate (MTX), it can reduce the binding of methotrexate to protein, reduce its excretion from the kidneys, increase the blood concentration and increase toxic reactions. 9 The uric acid excretion effect of probenecid or sulfinpyrazone can be reduced by using this product at the same time. When the blood concentration of salicylate is 50mg/ml, it is significantly reduced, and it is even worse when it is 100-150mg/ml. In addition, probenecid can reduce the clearance rate of salicylate from the kidneys, thereby increasing the latter's blood concentration.

Sealed, store in a dry place.

50mg

Yabao Taiyuan Pharmaceutical Co., Ltd.

• Founded in:

  2003-12-01

• Address:

  No. 20 Dayun Road, Taiyuan Economic and Technological Development Zone

• Tax NO.:

  91140100757250466G

• Registered Funds:

  60 million yuan

• Email:

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