Diclofenac Sodium Enteric-Coated Tablets

Diclofenac sodium enteric-coated tablets exert their antipyretic, analgesic and anti-inflammatory effects by inhibiting cyclooxygenase, thereby reducing the synthesis of prostaglandins, and to a certain extent inhibiting lipoxygenase, thereby reducing the production of leukotrienes, bradykinin and other products.

Diclofenac sodium.

This product is an enteric-coated tablet, which appears white after removing the enteric coating.

① Relieve the symptoms of joint swelling and pain in various arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathies, gouty arthritis, rheumatic arthritis, etc.; ② Treat various non-articular soft tissue rheumatic pains, such as shoulder pain, tenosynovitis, bursitis, myalgia and pain caused by sports injuries, etc.; ③ Acute mild and moderate pain such as post-surgery, post-traumatic, post-strain, dysmenorrhea, toothache, headache, etc.; ④ It has an antipyretic effect on fever in adults and children.

⑴ As a regular dose, the initial daily dose is 100-150 mg (4-6 tablets). For mild patients or patients who need long-term treatment, the daily dose is 75-100 mg (3-4 tablets). The daily dose is usually taken in 2-3 times. ⑵ For primary dysmenorrhea, the daily dose is usually 50-150 mg (2-6 tablets), taken in divided doses. The initial dose should be 50-150 mg (2-6 tablets). If necessary, the dose can be increased within several menstrual cycles to a maximum dose of 200 mg/day (8 tablets/day). Once symptoms appear, treatment should be started immediately and continued for several days. The treatment plan depends on the symptoms. ⑶ Common dosage for children: 0.5-2.0 mg/kg per day, the maximum daily dose is 3.0 mg/kg, taken in 3 times.

① Gastrointestinal reaction: the most common adverse reaction, which occurs in about 10% of patients. It mainly includes stomach discomfort, burning sensation, acid reflux, poor appetite, nausea, etc., which can disappear after stopping the drug or symptomatic treatment. A few of them may have ulcers, bleeding, and perforation; ② Nervous system manifestations include headache, dizziness, drowsiness, excitement, etc.; ③ It causes edema, oliguria, electrolyte imbalance and other adverse reactions, which can disappear after stopping the drug and corresponding treatment in mild cases; ④ Other rare reactions include transient increase in serum transaminase, and very rare cases of jaundice, rash, arrhythmia, granulocytopenia, thrombocytopenia, etc., which can all recover after stopping the drug.

This product is contraindicated for patients who are allergic to it. It is contraindicated for patients who have asthma, urticaria or other allergic reactions caused by aspirin or other non-steroidal anti-inflammatory drugs.

Precautions for children: Children under 16 years old should not take this medicine. Precautions for pregnancy and lactation: Pregnant and lactating women should not take this medicine. Precautions for the elderly: This product may induce or aggravate gastrointestinal bleeding, ulcers and perforations in the elderly. Use with caution in elderly patients who are taking diuretics or have extracellular fluid loss.

(1) When used with alcohol or other nonsteroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. Long-term use with acetaminophen may increase the toxic side effects on the kidneys. (2) When used with aspirin or other salicylic acid drugs, the efficacy is not enhanced, but the incidence of gastrointestinal adverse reactions and bleeding tendency increases. (3) When used with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors, there is an increased risk of bleeding. (4) When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. (5) When used with verapamil and nifedipine, the blood concentration of this product increases. (6) This product can increase the blood concentration of digoxin. When used together, it is necessary to pay attention to adjusting the dose of digoxin. (7) This product can enhance the effect of antidiabetic drugs (including oral hypoglycemic drugs). (8) When used with antihypertensive drugs, this product may affect the latter's antihypertensive effect. (9) Probenecid can reduce the excretion of this product, increase its blood concentration, and thus increase its toxicity. Therefore, it is advisable to reduce the dosage of this product when used together. (10) This product can reduce the excretion of methotrexate, increase its blood concentration, and even reach toxic levels. Therefore, this product should not be used together with medium or large doses of methotrexate. (11) This product can reduce the effects of insulin and other hypoglycemic drugs, causing blood sugar to rise. (12) When used together with potassium-sparing diuretics, it can cause hyperkalemia. (13) Aspirin can reduce the bioavailability of this product.

Keep away from light, tightly closed and in a dry place.

25mg

24 months

Jiangxi Zezhong Pharmaceutical Co., Ltd.

• Founded in:

  2005-06-02

• Address:

  No. 78 Sanqingshan West Avenue, Shangrao City

• Tax NO.:

  9136110077587941XC

• Registered Funds:

  30 million yuan

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