Iohexol Injection

Pharmacological action: This product is a commonly used contrast agent for X-ray and CT examinations, and can be used in blood vessels, spinal canals, and body cavities. Animal test results show that this product has an enhancement effect on dog liver, abdominal aorta, and CT scan images.

The main ingredients of this product and their chemical names are: iohexol, N, N'-bis (2,3-dihydroxypropyl) -5- [N- (2,3-dihydroxypropyl) acetamido] -2,4,6-triiodo-1,3-benzenedicarbamide. Its molecular formula: C19H26I3N3O9, molecular weight: 821.14.

1. Intravascular application: This product is used clinically for urography and cardiovascular angiography in adults and children, as well as cerebral angiography, peripheral and various arterial angiography, venography, digital subtraction and CT enhanced scanning in adults. 2. Subarachnoid application: It is suitable for myelography in adults and children, and for CT scanning of the brain pool after subarachnoid injection. 3. Intracavitary application: It is suitable for various body cavity examinations, including oral administration. Such as arthrography; endoscopic retrograde pancreaticobiliary angiography (ERCP); hernia sac angiography; urography; hysterosalpingography; sialography and various gastrointestinal examinations using oral water-soluble contrast agents.

Reference table for intravascular application dosage Application items Concentration Dosage Notes Urethral angiography Adults Children >7kg <7kg 300mgI/ml or 350mgI/ml 240mgI/ml or 300mgI/ml 240mgI/ml or 300mgI/ml 40～80ml 40～80ml 4ml/kg 3ml/kg 3ml/kg 2ml/kg (maximum 40ml) In case of large doses of urinary tract angiography, higher concentrations of contrast agents can be used Arteriography Aorta and blood vessel angiography Selective cerebral arteriography Aortography Limb arteriography Other arteriography Venography (limbs) 300mgI/ml 300mgI/ml 350mgI/ml 300mgI/ml.

1A small number of patients may experience some mild reactions, such as: short-term warmth, slight pain, flushing, nausea/vomiting, mild chest pain, skin itching and urticaria. 2Headache, nausea and vomiting are the most common adverse reactions to myelography. Severe headaches lasting for several days may occur intermittently. Other mild adverse reactions found so far include short-term dizziness, back pain, neck pain or limb pain, and various sensory abnormalities. There have also been cases where EEG recordings showed unclear transient changes (slow waves). Aseptic meningitis has been found after myelography with water-soluble contrast agents. Similar situations have been reported when this product was used for myelography, but they were very mild and short-lived. 3There are also reports of delayed adverse reactions in some patients within hours to days after the contrast.

1. Patients with obvious thyroid disease. 2. Patients with a history of severe reaction to iohexol injection. 3. Patients with a history of epilepsy should not use iohexol in the subarachnoid space. 4. Lumbar puncture is contraindicated for patients with severe local infection or systemic infection who may develop bacteremia. 5. Since radiation exposure should be avoided as much as possible during pregnancy, the pros and cons of X-ray examinations need to be weighed. Unless the doctor deems it necessary, pregnant women should not use it. 6. Due to dose limitations, it is not advisable to repeat angiography immediately for those who fail to perform angiography.

Precautions for children: Precautions for pregnancy and lactation: Please refer to contraindications and precautions. Precautions for the elderly:

1. The use of contrast media may cause transient renal insufficiency, which may cause lactic acidosis in diabetic patients taking hypoglycemic drugs (metformin). As a precaution, biguanide hypoglycemic drugs should be discontinued 48 hours before the use of contrast media, and the medication should be resumed only after renal function is stable. 2. Patients treated with interleukin-2 within two weeks have an increased risk of delayed reactions (cold-like symptoms and skin reactions). 3. All iodine-containing contrast media may interfere with thyroid function tests. The iodine binding capacity of thyroid tissue may be reduced by contrast media and may take several days or even two weeks to fully recover. 4. High concentrations of contrast media in serum and urine can affect laboratory test results of bilirubin, protein or inorganic substances (such as iron, copper, calcium and phosphorus). These tests should not be performed on the day of contrast media use.

Keep away from light and store in a sealed container.

50ml:17.5g(Ⅰ)

Beijing Beilu Pharmaceutical Co., Ltd.

• Founded in:

  1992-09-05

• Address:

  No. 3, Shuiyuan West Road, Miyun District, Beijing

• Tax NO.:

  91110000102017145R

• Registered Funds:

  491.855896 yuan

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