Aspirin enteric-coated tablets

Most of this product can be absorbed in the upper part of the small intestine. However, enteric-coated tablets are absorbed slowly. The protein binding rate of aspirin is low, but the protein binding rate of hydrolyzed salicylate is 65% to 90%. The binding rate decreases accordingly when the blood concentration is high. The binding rate is also low during renal insufficiency and pregnancy. The t1/2 is 15 to 20 minutes; the length of the t1/2 of salicylate depends on the size of the dose and the pH value of urine. It is about 2 to 3 hours when a small dose is taken at one time; it can be more than 20 hours when a large dose is taken, and it can reach 5 to 18 hours when the drug is taken repeatedly. Most of this product is quickly hydrolyzed into salicylate in the gastrointestinal tract, liver and blood, and then metabolized in the liver. The metabolites are mainly salicylic acid (salicyluric acid) and glucuronic acid conjugates, and a small part is oxidized to gentisic acid (gentisic acid). The blood drug peak is reached 1 to 2 hours after a single dose. The blood drug concentration is 25 to 50?g/ml when analgesic and antipyretic; 150 to 300g/ml when anti-rheumatic and anti-inflammatory. The time required for blood drug concentration to reach a stable state increases with the daily dose. When taking large doses of drugs (such as anti-rheumatic drugs), it usually takes 7 days, but it takes 2 to 3 weeks or longer to achieve the best therapeutic effect. For patients who take large doses of drugs for a long time, because the main metabolic pathway of the drug is saturated, a slight increase in the dose can lead to a significant change in blood drug concentration. This product is excreted from the kidneys as bound metabolites and free salicylic acid. When the dosage is large, the excretion of unmetabolized salicylic acid increases. There can be great differences between individuals. The pH value of urine affects the excretion rate. In alkaline urine, the excretion rate is accelerated, and the amount of free salicylic acid increases. In acidic urine, the opposite is true.

The main ingredient of this product is aspirin. Its chemical name is 2-(acetoxy)benzoic acid. Molecular formula: C9H8O4 Molecular weight: 180.16

This product is an enteric-coated tablet, which appears white after removing the coating.

Inhibit platelet aggregation, prevent thrombosis, treat and prevent transient ischemic attack, cerebral thrombosis, coronary heart disease, myocardial infarction, migraine, artificial heart valves, arteriovenous leakage and other post-operative thrombosis, thromboangiitis obliterans, etc.

Oral administration: Children aged 8 to 14 years, 1 tablet at a time; children aged 14 years and above and adults, 1 to 2 tablets at a time; if fever or pain persists, the medication can be repeated every 4 to 6 hours, not more than 4 times in 24 hours.

1 Common gastrointestinal reactions include nausea, vomiting, upper abdominal discomfort or pain. 2 Less common or rare reactions include (1) gastrointestinal bleeding or ulcers, manifested as bloody or tarry stools, severe stomach pain or vomiting of bloody or coffee-like substances, which are more common in patients taking large doses of the drug. (2) Bronchospasm-induced allergic reactions, manifested as dyspnea or asthma. (3) Skin allergic reactions, manifested as rash, urticaria, itchy skin, etc. (4) Hematuria, dizziness and liver damage.

1 Pregnant women and breastfeeding women are prohibited from using this product. 2 People with asthma, nasal polyposis syndrome, and those who are allergic to aspirin and other antipyretic analgesics are prohibited from using this product. 3 People with hemophilia, thrombocytopenia, or active ulcer disease are prohibited from using this product.

Precautions for children: Pediatric patients, especially those with fever and dehydration, are prone to toxic reactions. The use of this product in children with acute febrile diseases, especially influenza and chickenpox, may be associated with the development of Reye's syndrome, which is rare in China. Precautions for pregnancy and lactation: This product easily passes through the placenta. Animal experiments show that the use of this product in the first 3 months of pregnancy can cause teratogenesis, such as spina bifida, skull cleft, facial cleft, leg deformity, and incomplete development of the central nervous system, internal organs and bones. There are also reports of fetal defects in humans after the use of this product. In addition, long-term and large-scale use of this product in the last 3 months of pregnancy can prolong the pregnancy period and increase the risk of post-term labor syndrome and antepartum hemorrhage. Use in the last 2 weeks of pregnancy can increase the risk of fetal hemorrhage or neonatal hemorrhage. Long-term use of the drug in the late pregnancy may also cause the fetal ductus arteriosus to contract or close early, leading to persistent pulmonary hypertension and heart failure in the newborn. It has been reported that excessive use or abuse of this product in late pregnancy has increased the incidence of stillbirth or neonatal death (possibly due to ductus arteriosus atresia, antepartum hemorrhage or low body weight). However, the above adverse reactions have not been found in general therapeutic doses. This product can be excreted in breast milk. When lactating women take 650 mg orally, the drug concentration in breast milk can reach 173-483 μg/ml after 5-8 hours. Therefore, long-term high-dose medication may cause adverse reactions in infants. Precautions for the elderly: Elderly patients are prone to toxic reactions when taking this product due to decreased renal function.

1 This product should not be used with anticoagulants (such as dicoumarol, heparin) and thrombolytic drugs (streptokinase). 2 Antacids such as sodium bicarbonate can increase the excretion of this product in urine, causing a decrease in blood drug concentration, and should not be used together. 3 This product can increase gastrointestinal adverse reactions when used with glucocorticoids (such as dexamethasone, etc.). 4 This product can enhance the effects of oral hypoglycemic drugs and methotrexate, and should not be used together. 5 If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.

Keep away from light and sealed in a dry place.

0.3 g

60 months, do not use after the expiration date.

Heifei Jiulian Pharma Co., Ltd.

• Founded in:

  2001-08-01

• Address:

  Anhui Changfeng Shuangfeng Economic Development Zone

• Tax NO.:

  913401217300302871

• Registered Funds:

  1 million yuan

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