Flunarizine Hydrochloride Capsules

Flunarizine hydrochloride is a selective calcium antagonist that can block excessive calcium ions from entering cells across the membrane, preventing excessive intracellular calcium load. It can also prevent a large amount of calcium from entering neurons during ischemia and hypoxia, improve brain microcirculation and neuronal metabolism, inhibit cerebral vasospasm, platelet aggregation and increased blood viscosity, and also has a cell membrane stabilizing effect. This product is highly lipid-soluble and easily penetrates the blood-brain barrier. This product has no effect on cardiac contraction and conduction.

Flunarizine hydrochloride Chemical name: (E)-1-[bis(4-fluorophenyl)methyl]-4-(2-propenyl-3-phenyl)-piperazine dihydrochloride Molecular formula: C26H26F2N22HCL Molecular weight: 477.42.

This product is a capsule, and the contents are white powder.

1. Insufficient blood supply to the brain, vertebral artery ischemia, cerebral thrombosis, etc.; 2. Tinnitus, dizziness; 3. Prevention of migraine; 4. Auxiliary treatment of epilepsy.

1. Preventive treatment of migraine. Starting dose: 10 mg per night for patients under 65 years old, 5 mg per night for patients over 65 years old. Maintenance treatment: If the efficacy is satisfactory and the patient needs maintenance treatment, the dose should be reduced to five days per week (same dose as above). 2. Vertigo: The daily dose should be the same as above, but the drug should be discontinued in time after the symptoms are controlled. The initial course of treatment is usually less than 2 months.

1. The most common adverse reactions (often transient) are: drowsiness and/or fatigue (20%), and some patients may also experience weight gain (and/or increased appetite) (11%). 2. The following serious adverse reactions are occasionally seen (seen in long-term users): depression, which is more likely to occur in female patients with a history of depression. Extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, oral and mandibular movement disorders, tremors, etc.) are more likely to occur in the elderly. 3. Rare adverse reactions reported include: Gastrointestinal reactions: heartburn, nausea, stomach pain. Central nervous system: insomnia, anxiety. 4. Others: galactorrhea, dry mouth, muscle pain and rash.

1. This drug is contraindicated in patients with a history of allergy or depression, and should not be used in patients with acute cerebral hemorrhage. 2. Children should use it with caution. 3. Pregnant and lactating women should not use it.

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Not suitable for pregnant and lactating women. Precautions for the elderly: Because the nervous system of elderly patients is more sensitive and their metabolic capacity is weaker, the dosage should be reduced as appropriate.

When this product is used in combination with alcohol, hypnotics or sedatives, excessive sedation may occur. This product is not contraindicated for patients using beta-receptor blockers.

Keep away from light and store in sealed container.

Calculated as C26H26F2N2 5mg

36 months

Shaanxi Yishengtang Pharmaceutical Co., Ltd.

• Founded in:

  2001-12-14

• Address:

  Lijia Tower, Yintai District, Tongchuan City, Shaanxi Province

• Tax NO.:

  91610200732671512W

• Registered Funds:

  5.3 million yuan

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