Recombinant human growth hormone for injection
Function and Efficacy
1. Recombinant human growth hormone has the same effect as endogenous growth hormone in the human body, stimulating the differentiation and proliferation of epiphyseal chondrocytes, stimulating the growth of cartilage matrix cells, stimulating the differentiation and proliferation of osteoblasts, causing accelerated linear growth and widening of bones; 2. Promotes systemic protein synthesis, corrects the negative nitrogen balance after surgery and other traumas, corrects hypoproteinemia caused by severe infection and cirrhosis, stimulates immunoglobulin synthesis, stimulates the proliferation of lymphoid tissue, macrophages and lymphocytes, and enhances anti-infection ability; 3. Stimulates the synthesis of fibroblasts and macrophages in burn wounds and surgical incisions, and accelerates wound healing; promotes myocardial protein synthesis, increases myocardial contractility, reduces myocardial oxygen consumption, regulates fat metabolism, and reduces serum cholesterol and low-density lipoprotein levels; supplements insufficient or deficient growth hormone, and regulates fat metabolism, bone metabolism, and cardiorenal function in adults.
Ingredients
Recombinant human growth hormone.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| SomatonormIngredients |
1. Stimulate the differentiation and proliferation of epiphyseal chondrocytes, stimulate the growth of cartilage matrix cells, stimulate the differentiation and proliferation of osteoblasts, causing accelerated linear growth and widening of bones; 2. Promote systemic protein synthesis, correct the negative nitrogen balance after surgery and other traumas, correct hypoproteinemia caused by severe infection and cirrhosis; stimulate immunoglobulin synthesis, stimulate the proliferation of lymphoid tissue, macrophages and lymphocytes, and enhance anti-infection ability; 3. Stimulate the synthesis of fibroblasts and macrophages in burn wounds and surgical incisions, and accelerate wound healing; promote myocardial protein synthesis, increase myocardial contractility, reduce myocardial oxygen consumption, regulate fat metabolism, and reduce serum cholesterol and low-density lipoprotein levels; supplement the insufficiency or deficiency of growth hormone, and regulate fat metabolism, bone metabolism, and cardiorenal function in adults. More |
82030-87-3 | 0 |
Appearance
This product is white freeze-dried powder.
Indication
It is used for growth hormone deficiency in children and adults, Turner's syndrome, growth failure caused by chronic renal failure in children, hypermetabolic state (negative nitrogen balance) after surgery and trauma, burns, and sepsis.
Usage and Dosage
Before use, slowly add 1 ml of water for injection to the freeze-dried rhGH along the bottle wall, shake gently to dissolve it completely, and do not shake it violently. The dosage for promoting growth in children varies from person to person. The recommended dosage is 0.1~0.15IU/kg body weight/day, once a day, subcutaneous injection, and the course of treatment is 3 months to 3 years, or follow the doctor's advice. The recommended dosage for the treatment of severe burns is 0.2~0.4IU/kg body weight/day, once a day, subcutaneous injection, and the course of treatment is generally about 2 weeks.
Adverse Reactions
Growth hormone can cause transient hyperglycemia, which usually returns to normal with prolonged medication or after discontinuation. In clinical trials, about 1% of short children had side effects, common local transient reactions at the injection site (pain, numbness, redness and swelling, etc.) and symptoms of fluid retention (peripheral edema, joint pain or myalgia). These side effects occur earlier, but the incidence decreases with medication time, and rarely affect daily activities. Long-term injection of recombinant human growth hormone causes antibody production in a small number of patients, with low antibody binding ability and no definite clinical significance. However, if the expected growth effect is not achieved, antibodies may be produced, and if the antibody binding ability exceeds 2mg/L, it may affect the efficacy.
Precautions
1. Children with closed epiphyses are contraindicated. 2. Patients with symptoms of tumor progression are contraindicated. 3. Critically ill patients with severe systemic infection and those in acute shock are contraindicated.
Special Population Medication
Precautions for children: There is no significant difference between children and adults in the pharmacology, toxicology and pharmacokinetics of growth hormone, and it can be used safely according to body weight. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: There is no systematic clinical research on the use of growth hormone in the elderly.
Drug Interactions
Concurrent use of glucocorticoids may inhibit the hormone response, so the dosage of glucocorticoids in growth hormone therapy should not exceed 10-15 mg hydrocortisone/m2 body surface area. Concurrent use of non-androgenic steroids can further increase growth rate.
Storage
Store at 2~8℃ away from light. The dissolved solution can be refrigerated at 2~8℃ for 48 hours.
Packaging Specification
4IU/1.33mg/vial
Validity Period
24 months.
Manufacturer
Anhui Anke Biotechnology (Group) Co., Ltd.
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Founded in:
2000-09-28 -
Address:
K-1, Customs Road, High-tech Zone, No. 669, Changjiang West Road, Hefei, Anhui Province -
Tax NO.:
91340100149030777L -
Registered Funds:
1,672,553,658 yuan -
Website:
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Email: