MLN9708
1201902-80-8
99%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName MLN9708 Cat No CEI-0224 Description MLN9708 can inhibit CT-L Proteasome and 20S proteasome with IC50 of 5 nM and 3.4 nM. CAS No 1201902-80-8 Molecular Weight 517.12 Purity >99% Storage 2 years at -20centigrade Powder Targets CT-L Proteasome, 20S proteasome Molecular Formula C20H23BCl2N2O9 Chemical Name 4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Solubility DMSO 103 mg/mL Water In vitro MLN9708, a selective, orally bioavailable, second-generation proteasome inhibitor. MLN2238 is the biologically active form of MLN9708. In studies where a solution of MLN9708 was added directly into rat, dog, or human plasma and immediately extracted and analyzed by HPLC, only MLN2238 could be identified. At higher concentrations, it also inhibited the caspase-like ( beta 1) and trypsin-like ( beta 2) proteolytic sites (IC 50 of 31 and 3,500 nmol/L). In vivo MLN2238 inhibits growth of xenografted human MM cells in CB-17 SCID mice. category Inhibitors(c1514) cas_num 1201902-80-8 Basic Info-
Product Name:
MLN9708
Other Name:4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;MLN9708;MLN9708,MLN-9708,MLN 9708;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acidMLN9708;Ixazomib Citrate;4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dio;MLN 9708 analog
CAS No.:1201902-80-8
Molecular Formula:C20H23BCl2N2O9
InChIKeys:YTXSYWAKVMZICI-PVCZSOGJSA-N
Molecular Weight:517.12162
Exact Mass:516.087341
EC Number:-0
DSSTox ID:DTXSID10152721
HScode:29329990
Categories:
Characteristics-
PSA:
168
Density:1.47
Refractive Index:1.580
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product