Erlotinib hydrochloride
2 Inquiries
183319-69-9
99%
2026-08-08
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Erlotinib hydrochloride Cat No CEI-0053 Description Erlotinib (CP-358,774) can inhibit EGFR with IC50 of 2 nM. Alias Tarceva CAS No 183319-69-9 Molecular Weight 429.9 Purity >99% Storage 2 years at -20centigrade Powder Synonyms Tarceva Targets EGFR Molecular Formula C22H24CLN3O4 Chemical Name N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride Solubility DMSO 3 mg/mL Water In vitro As a potent EGFR inhibitor, erlotinib (CP-358,774) shows a great inhibition to EGFR. Erlotinib (CP-358,774) can inhibit EGFR with IC50 of 2 nM by bind to the adenosine triphosphate (ATP) binding site of EGFR. As triphosphate (ATP) binding site of EGFR does not work, autophosphorylation of EGFR is blocked by Erlotinib. For cell lines (1)The proliferation of DiFi cells is strongly inhibited by Erlotinib (CP-358,774) with an IC50 of 100 nM. (2)The HN5 human head and neck tumor cell line, which also expresses a very high level of the EGFR, is markedly inhibited by CP-358,774 at concentrations as low as 50 nM and is completely blocked at 250 nM. (3)Erlotinib shows great inhibition to NSCLC. (4) Erlotinib inhibits the proliferation of DiFi human colon tumor cells at submicromolar concentrations in cell culture and blocks cell cycle progression at the G1 phase. In vivo In vivo studies show that erlotinib has activity against human colorectal, head and neck, non-small cell lung, and pancreatic tumor cells category Antineoplastic Agents(c1417) cas_num 183319-69-9 Basic Info-
Product Name:
Erlotinib hydrochloride
Other Name:4-Quinazolinamine,N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride (1:1);4-Quinazolinamine,N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-,monohydrochloride;CP 358774;OSI 774;Tarceva;6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride;[6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride;Erlotinib hydrochloride
CAS No.:183319-69-9
Molecular Formula:C22H23N3O4.ClH
InChIKeys:InChIKey=GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Molecular Weight:429.89700
Exact Mass:429.14600
UNII:DA87705X9K
NSC Number:718781
DSSTox ID:DTXSID10171412
NCI Thesaurus Code:C2693
ATC Code:L01EB02
HScode:2933990090
Categories:
Characteristics-
PSA:
74.73000
XLogP3:4.28010
Appearance:White or off-white powder
Melting Point:219-221 °C @ Solvent: Methanol
Boiling Point:553.6ºC at 760 mmHg
Flash Point:288.6ºC
Vapor Pressure:4.52E-12mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
ERLOTINIB HCL
3.00 KG Dec 31, 2024
Pakistan
Erlotinib Hydrochloride
1 KG Jun 23, 2025 Post an enquiry for this product
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