BMS-345541
547757-23-3
0.98%
2026-07-08
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BMS-345541 Cat No CEI-1250 Description BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC50 values of 4 μM and 0.3 μM, respectively. Product Overview BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC50 values of 4μM and 0.3μM, respectively. BMS-345541 is a highly selective inhibitor of IKK that inhibits NF-κB-dependent transcription of pro-inflammatory cytokines both in vitro and in vivo. This specificity is proved in the assay measuring the IKK-2-catalyzed phosphorylation of GST-IκB. In this assay, BMS-345541 fails to inhibit other serine/threonine and tyrosine kinases. This selectivity is also evident in cells, only the stimulus-induced phosphorylation of IκB was inhibited by BMS-345541 whereas other signal transduction cascades were unaffected. Since the IKK/ NFκB pathway is important for viability of leukemic cells and is a predictor of relapse in T-ALL, BMS-345541 is tested in some T-ALL cell lines. It is found that BMS-345541 can induce apoptosis and an accumulation of cells in the G2/M phase of the cell cycle. BMS-345541 can be used in combination with traditional therapies to overcome resistance to chemotherapeutic agents CAS No 547757-23-3 Molecular Weight 291.78 Purity 0.98 Storage Store at -20°C Synonyms BMS-345541 hydrochloride; BMS 345541 hydrochloride Targets IKK IC50 4 μM; 0.3 μM Molecular Formula C14H18ClN5 Chemical Name N-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; hydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 547757-23-3 Basic Info-
Product Name:
BMS-345541
Other Name:N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediaminehydrochloride;BMS 345541 (HCl Salt);BMS345541 (HCl Salt);BMS 345541 hydrochloride;BMS345541 hydrochloride;BMS-345541 hydrochloride;BMS-345541 HCl
CAS No.:547757-23-3
Molecular Formula:C14Cl1H18N5
InChIKeys:MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Molecular Weight:291.78
Exact Mass:291.125061
Categories:
Characteristics-
PSA:
68.2
XLogP3:3.44520
Appearance:solid
Boiling Point:449.5°C at 760 mmHg
Flash Point:225.6ºC
Water Solubility:DMSO: 18 mg/mL, soluble
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product