Dapagliflozin
12 Inquiries
461432-26-8
0.98%
2026-08-21
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Dapagliflozin Cat No CEI-1307 Description Dapagliflozin is a potent and selective inhibitor of hSGLT2 with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Product Overview Selective inhibition of SGLT2 has been proposed to aid in the normalization of plasma glucose levels in patients with diabetes by preventing the renal glucose reabsorption process and promoting glucose excretion in urine. Dapagliflozin is a potent, selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) inhibitor. CAS No 461432-26-8 Molecular Weight 408.87 Purity 0.98 Storage Store at -20°C Targets SGLT2 IC50 1.1 nM (EC50) Molecular Formula C21H25ClO6 Chemical Name (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro EC50 values of 1.1 nM for hSGLT2 and 1.4 μM for hSGLT1 determined for Dapagliflozin corresponded to 1200-fold selectivity for SGLT2 as compared with phlorizin's 10-fold selectivity. Dapagliflozin inhibitory potencies against rat SGLT (rSGLT)2 and hSGLT2 were comparable, but the selectivity of Dapagliflozin for rSGLT2 versus rSGLT1 decreased to 200-fold. In vivo In vivo, dapagliflozin acutely induced renal glucose excretion in diabetic and normal rats, improved glucose tolerance in normal rats, as well as reduced hyperglycemia in Zucker diabetic fatty rats after single oral doses ranging between 0.1 and 1.0 mg/kg levels and body weight in treatment-naive patients with type 2 diabetes. Dapagliflozin was well tolerated. category Blood Glucose Regulators(c1133) cas_num 461432-26-8 Basic Info-
Product Name:
Dapagliflozin
Other Name:D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-,(1S)-;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol;Dapagliflozin;BMS 512148;(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol;2195352-53-3
CAS No.:461432-26-8
Molecular Formula:C21H25ClO6
InChIKeys:InChIKey=JVHXJTBJCFBINQ-ADAARDCZSA-N
Molecular Weight:408.875
Exact Mass:408.87
EC Number:1592732-453-0
UNII:1ULL0QJ8UC
NCI Thesaurus Code:C78126
ATC Code:A10BD|A10BK01|A - Alimentary tract and metabolism
Categories:
Characteristics-
PSA:
99.4
XLogP3:2.3
Density:1.349
Melting Point:65
Boiling Point:609°C
Flash Point:322.1±31.5 °C
Refractive Index:1.614
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Eye irritation, Category 2
Reproductive toxicity, Category 1B
Reproductive toxicity, Additional category for effects on or via lactation
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
H362 May cause harm to breast-fed children
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History12 Inquiries
Country Product Purchase Quantity Date Posted 
Austria
Dapagliflozin
1.00 G Jul 14, 2026 
United Arab Emirates
Dapagliflozin
5 KG Jul 15, 2026 
India
Dapagliflozin
0.10 G Jul 7, 2026
India
Dapagliflozin
7 MT Nov 24, 2025 
United States
Dapagliflozin
10 G Jul 13, 2026
India
Zinc Carnosine
50 KG Apr 23, 2026 
Germany
Dapagliflozin
1 KG Mar 31, 2026
India
Dapagliflozin
1 KG Nov 5, 2024
India
Dapagliflozin
200 KG Jun 12, 2024
India
Dapagliflozin
15 KG Jun 5, 2026 
Portugal
Dapagliflozin
1 KG Jun 9, 2025 
Canada
High Quality Dapagliflozin Powder CAS :461432-26-8 with Best Price
4 G Sep 9, 2023 Post an enquiry for this product